Cargando…

Epigenetic regulation of N6‐methyladenosine modifications in obesity

Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases. N6‐methyladenosine (m6A) modification is the mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Mingli, Zhang, Xinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354493/
https://www.ncbi.nlm.nih.gov/pubmed/33979018
http://dx.doi.org/10.1111/jdi.13571
_version_ 1783736604254273536
author Sun, Mingli
Zhang, Xinan
author_facet Sun, Mingli
Zhang, Xinan
author_sort Sun, Mingli
collection PubMed
description Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases. N6‐methyladenosine (m6A) modification is the most common form of ribonucleic acid modification, which has attracted increasing interest of researchers in recent years, as it is reported that m6A has vital functions in diseases and everyday life activities. Recent studies showed that m6A modification was decreased in obese adipose tissue, and appeared to play a regulatory role in many obesity‐associated biological processes, including adipogenesis, lipid metabolism and insulin resistance. In this review, we discussed the emerging advances in m6A modification in obesity to provide a novel therapeutic strategy for fighting against obesity.
format Online
Article
Text
id pubmed-8354493
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-83544932021-08-15 Epigenetic regulation of N6‐methyladenosine modifications in obesity Sun, Mingli Zhang, Xinan J Diabetes Investig Review Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases. N6‐methyladenosine (m6A) modification is the most common form of ribonucleic acid modification, which has attracted increasing interest of researchers in recent years, as it is reported that m6A has vital functions in diseases and everyday life activities. Recent studies showed that m6A modification was decreased in obese adipose tissue, and appeared to play a regulatory role in many obesity‐associated biological processes, including adipogenesis, lipid metabolism and insulin resistance. In this review, we discussed the emerging advances in m6A modification in obesity to provide a novel therapeutic strategy for fighting against obesity. John Wiley and Sons Inc. 2021-06-03 2021-08 /pmc/articles/PMC8354493/ /pubmed/33979018 http://dx.doi.org/10.1111/jdi.13571 Text en © 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Sun, Mingli
Zhang, Xinan
Epigenetic regulation of N6‐methyladenosine modifications in obesity
title Epigenetic regulation of N6‐methyladenosine modifications in obesity
title_full Epigenetic regulation of N6‐methyladenosine modifications in obesity
title_fullStr Epigenetic regulation of N6‐methyladenosine modifications in obesity
title_full_unstemmed Epigenetic regulation of N6‐methyladenosine modifications in obesity
title_short Epigenetic regulation of N6‐methyladenosine modifications in obesity
title_sort epigenetic regulation of n6‐methyladenosine modifications in obesity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354493/
https://www.ncbi.nlm.nih.gov/pubmed/33979018
http://dx.doi.org/10.1111/jdi.13571
work_keys_str_mv AT sunmingli epigeneticregulationofn6methyladenosinemodificationsinobesity
AT zhangxinan epigeneticregulationofn6methyladenosinemodificationsinobesity