Cargando…

Nanoscale 3D EM reconstructions reveal intrinsic mechanisms of structural diversity of chemical synapses

Chemical synapses of shared cellular origins have remarkably heterogeneous structures, but how this diversity is generated is unclear. Here, we use three-dimensional (3D) electron microscopy and artificial intelligence algorithms for image processing to reconstruct functional excitatory microcircuit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Yongchuan, Uytiepo, Marco, Bushong, Eric, Haberl, Matthias, Beutter, Elizabeth, Scheiwe, Frederieke, Zhang, Weiheng, Chang, Lyanne, Luu, Danielle, Chui, Brandon, Ellisman, Mark, Maximov, Anton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354523/ https://www.ncbi.nlm.nih.gov/pubmed/33826888 http://dx.doi.org/10.1016/j.celrep.2021.108953

Ejemplares similares

Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
por: Zhu, Yongchuan, et al.
Publicado: (2019)

Verifying, Challenging, and Discovering New Synapses Among Fully EM-Reconstructed Neurons in the Leech Ganglion
por: Pipkin, Jason E., et al.
Publicado: (2018)

Mitochondrial morphology provides a mechanism for energy buffering at synapses
por: Garcia, Guadalupe C., et al.
Publicado: (2019)

Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease
por: Wilke, Scott A., et al.
Publicado: (2014)

SynEM, automated synapse detection for connectomics
por: Staffler, Benedikt, et al.
Publicado: (2017)

SynapsEM: Computer-Assisted Synapse Morphometry
por: Watanabe, Shigeki, et al.
Publicado: (2020)

Resolution Matters: Correlating Quantitative Proteomics and Nanoscale‐Precision Microscopy for Reconstructing Synapse Identity
por: Miklosi, Andras Gabor, et al.
Publicado: (2018)

Genetic Probe for Visualizing Glutamatergic Synapses and Vesicles by 3D Electron Microscopy
por: Steinkellner, Thomas, et al.
Publicado: (2021)

Crossbar Nanoscale HfO(2)-Based Electronic Synapses
por: Matveyev, Yury, et al.
Publicado: (2016)

Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses
por: Catsburg, Lisa AE, et al.
Publicado: (2022)

Control of Ca(2+) signals by astrocyte nanoscale morphology at tripartite synapses
por: Denizot, Audrey, et al.
Publicado: (2022)

Nanoscale CAR Organization at the Immune Synapse Correlates with CAR-T Effector Functions
por: Sajman, Julia, et al.
Publicado: (2023)

An intelligent workflow for sub-nanoscale 3D reconstruction of intact synapses from serial section electron tomography
por: Chang, Sheng, et al.
Publicado: (2023)

Intrinsic Sources and Functional Impacts of Asymmetry at Electrical Synapses
por: Mendoza, Austin J., et al.
Publicado: (2022)

Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific
por: Hruska, Martin, et al.
Publicado: (2022)

Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons
por: Dharmasri, Poorna A., et al.
Publicado: (2023)

Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses
por: Gookin, Sara E., et al.
Publicado: (2022)

Near-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses
por: Paviolo, Chiara, et al.
Publicado: (2022)

Wrapping glia regulates neuronal signaling speed and precision in the peripheral nervous system of Drosophila
por: Kottmeier, Rita, et al.
Publicado: (2020)

Measuring expansion from macro‐ to nanoscale using NPC as intrinsic reporter
por: Pesce, Luca, et al.
Publicado: (2019)

Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin
por: Muellerleile, Julia, et al.
Publicado: (2020)

Cointegration of single-transistor neurons and synapses by nanoscale CMOS fabrication for highly scalable neuromorphic hardware
por: Han, Joon-Kyu, et al.
Publicado: (2021)

Simultaneous emulation of synaptic and intrinsic plasticity using a memristive synapse
por: Sung, Sang Hyun, et al.
Publicado: (2022)

Visualizing the interplay of Dirac mass gap and magnetism at nanoscale in intrinsic magnetic topological insulators
por: Liu, Mengke, et al.
Publicado: (2022)

InterCells: A Generic Monte-Carlo Simulation of Intercellular Interfaces Captures Nanoscale Patterning at the Immune Synapse
por: Neve-Oz, Yair, et al.
Publicado: (2018)

Super-Resolution Microscopy Reveals a Nanoscale Organization of Acetylcholine Receptors for Trans-Synaptic Alignment at Neuromuscular Synapses
por: York, Amanda L., et al.
Publicado: (2017)

Iron-specific Signal Separation from within Heavy Metal Stained Biological Samples Using X-Ray Microtomography with Polychromatic Source and Energy-Integrating Detectors
por: Katchalski, Tsvi, et al.
Publicado: (2018)

Two Pathways for the Activity-Dependent Growth and Differentiation of Synaptic Boutons in Drosophila
por: Vasin, Alexander, et al.
Publicado: (2019)

Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography
por: Böger, Carolin, et al.
Publicado: (2019)

High-Resolution Fluorescence Imaging Combined With Computer Simulations to Quantitate Surface Dynamics and Nanoscale Organization of Neuroligin-1 at Synapses
por: Lagardère, Matthieu, et al.
Publicado: (2022)

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus
por: Lloyd, Brian A, et al.
Publicado: (2023)

A pipeline for STED super-resolution imaging and Imaris analysis of nanoscale synapse organization in mouse cortical brain slices
por: Kruzich, Ezra, et al.
Publicado: (2023)

Folding of an Intrinsically Disordered Iron-Binding Peptide in Response to Sedimentation Revealed by Cryo-EM
por: Davidov, Geula, et al.
Publicado: (2020)

A fast forward 3D connection algorithm for mitochondria and synapse segmentations from serial EM images
por: Li, Weifu, et al.
Publicado: (2018)

Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse
por: Kim, Hye-Hyun, et al.
Publicado: (2022)

Direct Imaging of Ion Migration in Amorphous Oxide Electronic Synapses with Intrinsic Analog Switching Characteristics
por: Tsurumaki-Fukuchi, Atsushi, et al.
Publicado: (2023)

Deceleration of probe beam by stage bias potential improves resolution of serial block-face scanning electron microscopic images
por: Bouwer, James C., et al.
Publicado: (2016)

Sparse force-bearing bridges between neighboring synaptic vesicles
por: Wesseling, John F., et al.
Publicado: (2019)

Three-Dimensional Reconstruction of Serial Mouse Brain Sections: Solution for Flattening High-Resolution Large-Scale Mosaics
por: Berlanga, Monica L., et al.
Publicado: (2011)

A workflow for the automatic segmentation of organelles in electron microscopy image stacks
por: Perez, Alex J., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_sja801unpkd97c7ph92873e1tp