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The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders

Postoperative neurocognitive disorder (PND) increases the length of hospital stay, mortality, and risk of long-term cognitive impairment. Perioperative sleep disturbance is prevalent and commonly ignored and may increase the risk of PND. However, the role of perioperative sleep disturbances in PND r...

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Autores principales: Wang, Xuan, Hua, Dongyu, Tang, Xiaole, Li, Shan, Sun, Rao, Xie, Zheng, Zhou, Zhiqiang, Zhao, Yilin, Wang, Jintao, Li, Shiyong, Luo, Ailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354730/
https://www.ncbi.nlm.nih.gov/pubmed/34393534
http://dx.doi.org/10.2147/NSS.S320745
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author Wang, Xuan
Hua, Dongyu
Tang, Xiaole
Li, Shan
Sun, Rao
Xie, Zheng
Zhou, Zhiqiang
Zhao, Yilin
Wang, Jintao
Li, Shiyong
Luo, Ailin
author_facet Wang, Xuan
Hua, Dongyu
Tang, Xiaole
Li, Shan
Sun, Rao
Xie, Zheng
Zhou, Zhiqiang
Zhao, Yilin
Wang, Jintao
Li, Shiyong
Luo, Ailin
author_sort Wang, Xuan
collection PubMed
description Postoperative neurocognitive disorder (PND) increases the length of hospital stay, mortality, and risk of long-term cognitive impairment. Perioperative sleep disturbance is prevalent and commonly ignored and may increase the risk of PND. However, the role of perioperative sleep disturbances in PND remains unclear. Nocturnal sleep plays an indispensable role in learning, memory, and maintenance of cerebral microenvironmental homeostasis. Hospitalized sleep disturbances also increase the incidence of postoperative delirium and cognitive dysfunction. This review summarizes the role of perioperative sleep disturbances in PND and elucidates the potential mechanisms underlying sleep-deprivation-mediated PND. Activated neuroinflammation and oxidative stress; impaired function of the blood-brain barrier and glymphatic pathway; decreased hippocampal brain-derived neurotrophic factor, adult neurogenesis, and sirtuin1 expression; and accumulated amyloid-beta proteins are associated with PND in individuals with perioperative sleep disorders. These findings suggest that the improvement of perioperative sleep might reduce the incidence of postoperative delirium and postoperative cognitive dysfunction. Future studies should further investigate the role of perioperative sleep disturbance in PND.
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spelling pubmed-83547302021-08-12 The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders Wang, Xuan Hua, Dongyu Tang, Xiaole Li, Shan Sun, Rao Xie, Zheng Zhou, Zhiqiang Zhao, Yilin Wang, Jintao Li, Shiyong Luo, Ailin Nat Sci Sleep Review Postoperative neurocognitive disorder (PND) increases the length of hospital stay, mortality, and risk of long-term cognitive impairment. Perioperative sleep disturbance is prevalent and commonly ignored and may increase the risk of PND. However, the role of perioperative sleep disturbances in PND remains unclear. Nocturnal sleep plays an indispensable role in learning, memory, and maintenance of cerebral microenvironmental homeostasis. Hospitalized sleep disturbances also increase the incidence of postoperative delirium and cognitive dysfunction. This review summarizes the role of perioperative sleep disturbances in PND and elucidates the potential mechanisms underlying sleep-deprivation-mediated PND. Activated neuroinflammation and oxidative stress; impaired function of the blood-brain barrier and glymphatic pathway; decreased hippocampal brain-derived neurotrophic factor, adult neurogenesis, and sirtuin1 expression; and accumulated amyloid-beta proteins are associated with PND in individuals with perioperative sleep disorders. These findings suggest that the improvement of perioperative sleep might reduce the incidence of postoperative delirium and postoperative cognitive dysfunction. Future studies should further investigate the role of perioperative sleep disturbance in PND. Dove 2021-08-06 /pmc/articles/PMC8354730/ /pubmed/34393534 http://dx.doi.org/10.2147/NSS.S320745 Text en © 2021 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wang, Xuan
Hua, Dongyu
Tang, Xiaole
Li, Shan
Sun, Rao
Xie, Zheng
Zhou, Zhiqiang
Zhao, Yilin
Wang, Jintao
Li, Shiyong
Luo, Ailin
The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_full The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_fullStr The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_full_unstemmed The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_short The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
title_sort role of perioperative sleep disturbance in postoperative neurocognitive disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354730/
https://www.ncbi.nlm.nih.gov/pubmed/34393534
http://dx.doi.org/10.2147/NSS.S320745
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