Severity modeling of propionic acidemia using clinical and laboratory biomarkers

PURPOSE: To conduct a proof-of-principle study to identify subtypes of propionic acidemia (PA) and associated biomarkers. METHODS: Data from a clinically diverse PA patient population (https://clinicaltrials.gov/ct2/show/NCT02890342) were used to train and test machine learning models, identify PA-r...

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Detalles Bibliográficos
Autores principales: Shchelochkov, Oleg A., Manoli, Irini, Juneau, Paul, Sloan, Jennifer L., Ferry, Susan, Myles, Jennifer, Schoenfeld, Megan, Pass, Alexandra, McCoy, Samantha, Van Ryzin, Carol, Wenger, Olivia, Levin, Mark, Zein, Wadih, Huryn, Laryssa, Snow, Joseph, Chlebowski, Colby, Thurm, Audrey, Kopp, Jeffrey B., Chen, Kong Y., Venditti, Charles P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354856/
https://www.ncbi.nlm.nih.gov/pubmed/34007002
http://dx.doi.org/10.1038/s41436-021-01173-2

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