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Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2

The nucleoside metabolite of remdesivir, GS-441524 displays potent anti-SARS-CoV-2 efficacy, and is being evaluated in clinical as an oral antiviral therapeutic for COVID-19. However, this nucleoside has a poor oral bioavailability in non-human primates, which may affect its therapeutic efficacy. He...

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Detalles Bibliográficos
Autores principales:	Wei, Daibao, Hu, Tianwen, Zhang, Yumin, Zheng, Wei, Xue, Haitao, Shen, Jingshan, Xie, Yuanchao, Aisa, Haji A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354861/ https://www.ncbi.nlm.nih.gov/pubmed/34450570 http://dx.doi.org/10.1016/j.bmc.2021.116364

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