The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated conditional, inducible knock-out mice for Rpap3 to inactivate this core component of R2TP in the intestinal epithelium. In...

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Detalles Bibliográficos
Autores principales: Maurizy, Chloé, Abeza, Claire, Lemmers, Bénédicte, Gabola, Monica, Longobardi, Ciro, Pinet, Valérie, Ferrand, Marina, Paul, Conception, Bremond, Julie, Langa, Francina, Gerbe, François, Jay, Philippe, Verheggen, Céline, Tinari, Nicola, Helmlinger, Dominique, Lattanzio, Rossano, Bertrand, Edouard, Hahne, Michael, Pradet-Balade, Bérengère
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355188/
https://www.ncbi.nlm.nih.gov/pubmed/34376666
http://dx.doi.org/10.1038/s41467-021-24792-4

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