Cargando…

BCLX(L) gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma

Axonal degeneration of retinal ganglion cells (RGCs) causes blindness in glaucoma. Currently, there are no therapies that target axons to prevent them from degenerating. Activation of the BAX protein has been shown to be the determining step in the intrinsic apoptotic pathway that causes RGCs to die...

Descripción completa

Detalles Bibliográficos
Autores principales:	Donahue, Ryan J., Fehrman, Rachel L., Gustafson, Jenna R., Nickells, Robert W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355227/ https://www.ncbi.nlm.nih.gov/pubmed/34376637 http://dx.doi.org/10.1038/s41419-021-04068-x

Ejemplares similares

Loss of Retinogeniculate Synaptic Function in the DBA/2J Mouse Model of Glaucoma
por: Smith, Jennie C., et al.
Publicado: (2022)

Infection with flaviviruses requires BCLX(L) for cell survival
por: Suzuki, Tatsuya, et al.
Publicado: (2018)

Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma
por: Wilson, Gina N., et al.
Publicado: (2015)

The Contribution of Anterior Segment Abnormalities to Changes in Intraocular Pressure in the DBA/2J Mouse Model of Glaucoma: DBA/2J-Gpnmb(+)/SjJ Mice as Critical Controls
por: Rohowetz, Landon J., et al.
Publicado: (2022)

BclX(L) (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury
por: Marola, Olivia J., et al.
Publicado: (2022)

Characterization of Alzheimer's disease‐like neuropathology in Duchenne's muscular dystrophy using the DBA/2J mdx mouse model
por: Hayward, Grant C., et al.
Publicado: (2021)

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice
por: Howell, Gareth R, et al.
Publicado: (2013)

Effects of Dorzolamide on Retinal and Choroidal Blood Flow in the DBA/2J Mouse Model of Glaucoma
por: Chandra, Saurav, et al.
Publicado: (2016)

Erratum To: Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma
por: Wilson, Gina N., et al.
Publicado: (2015)

Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model
por: Hirt, Joshua, et al.
Publicado: (2018)

Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma
por: Williams, Pete A., et al.
Publicado: (2013)

Computational design of BclxL inhibitors that target transmembrane domain interactions
por: Duart, Gerard, et al.
Publicado: (2023)

Generating Embryonic Stem Cells from the Inbred Mouse Strain DBA/2J, a Model of Glaucoma and Other Complex Diseases
por: Reinholdt, Laura G., et al.
Publicado: (2012)

Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
por: Schlamp, Cassandra L, et al.
Publicado: (2006)

Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina
por: Dong, Ling-Dan, et al.
Publicado: (2013)

Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma
por: Buchanan, Rebecca A., et al.
Publicado: (2019)

Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma
por: Wilson, Gina N., et al.
Publicado: (2016)

Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma
por: Yang, Xiao-Ling, et al.
Publicado: (2018)

Distribution of Pigment Particles in Aqueous Drainage Structures in a DBA/2J Mouse Model of Pigmentary Glaucoma
por: Pu, Liping, et al.
Publicado: (2022)

High-throughput sequencing of the DBA/2J mouse genome
por: Wang, Xusheng, et al.
Publicado: (2010)

Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma
por: Dengler-Crish, Christine M., et al.
Publicado: (2014)

Impact of cerebral hypoperfusion–reperfusion on optic nerve integrity and visual function in the DBA/2J mouse model of glaucoma
por: Fraenkl, Stephan Alexander, et al.
Publicado: (2022)

New mouse model of acute adult T‐cell leukemia generated by transplantation of AKT, BCLxL, and HBZ‐transduced T cells
por: Kasugai, Yumiko, et al.
Publicado: (2016)

Effects of chronic mild hyperoxia on retinal and choroidal blood flow and retinal function in the DBA/2J mouse model of glaucoma
por: Muir, Eric R., et al.
Publicado: (2022)

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
por: Howell, Gareth R., et al.
Publicado: (2007)

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma
por: Williams, Pete A., et al.
Publicado: (2019)

Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells
por: Martin-Sanchez, Diego, et al.
Publicado: (2017)

Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in a Genetic DBA/2J Mouse Model of Glaucoma
por: Mead, Ben, et al.
Publicado: (2018)

Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
por: Howell, Gareth R, et al.
Publicado: (2007)

Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
por: Anderson, Michael G, et al.
Publicado: (2001)

Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice
por: Nair, K Saidas, et al.
Publicado: (2014)

Natural History of Glaucoma Progression in the DBA/2J Model: Early Contribution of Müller Cell Gliosis
por: Amato, Rosario, et al.
Publicado: (2023)

Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma (DBA/2J) mice
por: Yang, Yin, et al.
Publicado: (2023)

Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush
por: Templeton, Justin P, et al.
Publicado: (2009)

The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice
por: Harder, Jeffrey M., et al.
Publicado: (2012)

Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J
por: Fernández-Vega Cueto, Andrés, et al.
Publicado: (2020)

Diabetes Exacerbates the Intraocular Pressure-Independent Retinal Ganglion Cells Degeneration in the DBA/2J Model of Glaucoma
por: Amato, Rosario, et al.
Publicado: (2021)

C57BL/6J, DBA/2J, and DBA/2J.Gpnmb(+) mice have different visual signal processing in the inner retina
por: Porciatti, Vittorio, et al.
Publicado: (2010)

Presphenoidal synchondrosis fusion in DBA/2J mice
por: Adams, Allysa, et al.
Publicado: (2012)

By Altering Ocular Immune Privilege, Bone Marrow–derived Cells Pathogenically Contribute to DBA/2J Pigmentary Glaucoma
por: Mo, Jun-Song, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_m4fpd1jhh11055tvv4fd61qbm3