Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans

We test the hypothesis that endothelial cells adopt an inflammatory phenotype in functionally intact aged human subjects with radiographic evidence of white matter hyperintensity (WMH) suggestive of small cerebrovascular disease. Components of all three complement effector pathways and regulatory pr...

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Detalles Bibliográficos
Autores principales: Elahi, Fanny M., Harvey, Danielle, Altendahl, Marie, Brathaban, Nivetha, Fernandes, Nicole, Casaletto, Kaitlin B., Staffaroni, Adam M., Maillard, Pauline, Hinman, Jason D., Miller, Bruce L., DeCarli, Charles, Kramer, Joel H., Goetzl, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355229/
https://www.ncbi.nlm.nih.gov/pubmed/34376699
http://dx.doi.org/10.1038/s41598-021-91759-2

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