Cargando…

In silico characterisation of putative Plasmodium falciparum vaccine candidates in African malaria populations

Genetic diversity of surface exposed and stage specific Plasmodium falciparum immunogenic proteins pose a major roadblock to developing an effective malaria vaccine with broad and long-lasting immunity. We conducted a prospective genetic analysis of candidate antigens (msp1, ama1, rh5, eba175, glurp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ajibola, O., Diop, M. F., Ghansah, A., Amenga-Etego, L., Golassa, L., Apinjoh, T., Randrianarivelojosia, M., Maiga-Ascofare, O., Yavo, W., Bouyou-Akotet, M., Oyebola, K. M., Andagalu, B., D’Alessandro, U., Ishengoma, D., Djimde, A. A., Kamau, E., Amambua-Ngwa, A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355234/ https://www.ncbi.nlm.nih.gov/pubmed/34376744 http://dx.doi.org/10.1038/s41598-021-95442-4

Ejemplares similares

Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook
por: Ghansah, Anita, et al.
Publicado: (2019)

Plasmodium malariae structure and genetic diversity in sub-Saharan Africa determined from microsatellite variants and linked SNPs in orthologues of antimalarial resistance genes
por: Oriero, Eniyou C., et al.
Publicado: (2022)

The biology of unconventional invasion of Duffy-negative reticulocytes by Plasmodium vivax and its implication in malaria epidemiology and public health
por: Golassa, Lemu, et al.
Publicado: (2020)

Population genetic analysis of the Plasmodium falciparum circumsporozoite protein in two distinct ecological regions in Ghana
por: Amegashie, Elikplim A., et al.
Publicado: (2020)

Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection
por: Esoh, Kevin K., et al.
Publicado: (2021)

Genome-wide association study identifies novel candidate malaria resistance genes in Cameroon
por: Esoh, Kevin K, et al.
Publicado: (2023)

Genetic diversity and drug resistance surveillance of Plasmodium falciparum for malaria elimination: is there an ideal tool for resource-limited sub-Saharan Africa?
por: Apinjoh, Tobias O., et al.
Publicado: (2019)

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa
por: Ndwiga, Leonard, et al.
Publicado: (2021)

Pausing the Fight Against Malaria to Combat the COVID-19 Pandemic in Africa: Is the Future of Malaria Bleak?
por: Nghochuzie, Nora Nganyewo, et al.
Publicado: (2020)

Recent increase in low complexity polygenomic infections and sialic acid-independent invasion pathways in Plasmodium falciparum from Western Gambia
por: Nganyewo, Nora Nghochuzie, et al.
Publicado: (2023)

Pooled-DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum
por: Oyebola, Kolapo M., et al.
Publicado: (2017)

Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution
por: Rutledge, Gavin G., et al.
Publicado: (2017)

High prevalence and extended deletions in Plasmodium falciparum hrp2/3 genomic loci in Ethiopia
por: Golassa, Lemu, et al.
Publicado: (2020)

Sequence analysis of Plasmodium vivax Duffy binding proteins reveals the presence of unique haplotypes and diversifying selection in Ethiopian isolates
por: Golassa, Lemu, et al.
Publicado: (2021)

Assessment of antimalarial drug resistant markers in asymptomatic Plasmodium falciparum infections after 4 years of indoor residual spraying in Northern Ghana
por: Myers-Hansen, James L., et al.
Publicado: (2020)

Seroprevalence and Parasite Rates of Plasmodium malariae in a High Malaria Transmission Setting of Southern Nigeria
por: Oriero, Eniyou C., et al.
Publicado: (2020)

Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia
por: Abera, Deriba, et al.
Publicado: (2021)

Genome-wide SNP analysis of Plasmodium falciparum shows differentiation at drug-resistance-associated loci among malaria transmission settings in southern Mali
por: Coulibaly, Aoua, et al.
Publicado: (2022)

Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia
por: Tadele, Geletta, et al.
Publicado: (2023)

High cases of submicroscopic Plasmodium falciparum infections in a suburban population of Lagos, Nigeria
por: Umunnakwe, Florence A., et al.
Publicado: (2019)

Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon: cross-sectional study
por: Apinjoh, Tobias O., et al.
Publicado: (2017)

Applying next-generation sequencing to track falciparum malaria in sub-Saharan Africa
por: Tessema, Sofonias K., et al.
Publicado: (2019)

Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2 and multiplicity of infections in western Ethiopia following effective malaria interventions
por: Tadele, Geletta, et al.
Publicado: (2022)

Microsatellite markers reveal low levels of population sub-structuring of Plasmodium falciparum in southwestern Nigeria
por: Oyebola, Muyiwa K, et al.
Publicado: (2014)

Ethiopian Plasmodium vivax hypnozoites formation dynamics and their susceptibility to reference antimalarial drugs
por: Dembele, Laurent, et al.
Publicado: (2023)

Genetic Polymorphism of msp1 and msp2 in Plasmodium falciparum Isolates from Côte d'Ivoire versus Gabon
por: Yavo, William, et al.
Publicado: (2016)

Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria
por: Ajibaye, Olusola, et al.
Publicado: (2020)

Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria
por: Tola, Monday, et al.
Publicado: (2020)

Approaches to estimating inbreeding coefficients in clinical isolates of Plasmodium falciparum from genomic sequence data
por: O’Brien, John D., et al.
Publicado: (2016)

Genetic polymorphism of merozoite surface protein-1 in Plasmodium falciparum isolates from patients with mild to severe malaria in Libreville, Gabon
por: Bouyou-Akotet, Marielle Karine, et al.
Publicado: (2015)

Antenatal care visit attendance, intermittent preventive treatment and bed net use during pregnancy in Gabon
por: Bouyou-Akotet, Marielle Karine, et al.
Publicado: (2013)

Haplotype Analyses of Haemoglobin C and Haemoglobin S and the Dynamics of the Evolutionary Response to Malaria in Kassena-Nankana District of Ghana
por: Ghansah, Anita, et al.
Publicado: (2012)

Beyond SARS-CoV-2: Lessons That African Governments Can Apply in Preparation for Possible Future Epidemics
por: Oboh, Mary Aigbiremo, et al.
Publicado: (2020)

Diversity and behavioral activity of Anopheles mosquitoes on the slopes of Mount Cameroon
por: Kwi, Pilate N., et al.
Publicado: (2022)

Inferring Strain Mixture within Clinical Plasmodium falciparum Isolates from Genomic Sequence Data
por: O’Brien, John D., et al.
Publicado: (2016)

Translation of genomic epidemiology of infectious pathogens: Enhancing African genomics hubs for outbreaks
por: Oboh, Mary Aigbiremo, et al.
Publicado: (2020)

Challenges in the clinical development pathway for triple and multiple drug combinations in the treatment of uncomplicated falciparum malaria
por: Bassat, Quique, et al.
Publicado: (2022)

Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana
por: Aniweh, Yaw, et al.
Publicado: (2023)

Insecticide resistance in indoor and outdoor-resting Anopheles gambiae in Northern Ghana
por: Hamid-Adiamoh, Majidah, et al.
Publicado: (2020)

Allelic Diversity of MSP1 Gene in Plasmodium falciparum from Rural and Urban Areas of Gabon
por: Mawili-Mboumba, Denise Patricia, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kt06ti0fs8ilb0o9qac5ngvoot