Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis

Plasma hyaluronan (HA) increases systemically in type 2 diabetes (T2D) and the HA synthesis inhibitor, 4-Methylumbelliferone, has been proposed to treat the disease. However, HA is also implicated in normal physiology. Therefore, we generated a Hyaluronan Synthase 2 transgenic mouse line, driven by...

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Detalles Bibliográficos
Autores principales: Zhu, Yi, Li, Na, Huang, Mingyang, Bartels, Mason, Dogné, Sophie, Zhao, Shangang, Chen, Xi, Crewe, Clair, Straub, Leon, Vishvanath, Lavanya, Zhang, Zhuzhen, Shao, Mengle, Yang, Yongjie, Gliniak, Christy M., Gordillo, Ruth, Smith, Gordon I., Holland, William L., Gupta, Rana K., Dong, Bingning, Caron, Nathalie, Xu, Yong, Akgul, Yucel, Klein, Samuel, Scherer, Philipp E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355239/
https://www.ncbi.nlm.nih.gov/pubmed/34376643
http://dx.doi.org/10.1038/s41467-021-25025-4

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