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Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase

F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but the mechanism(s) leading to channel formation remain undefined. Here, to shed light on the structural requirements for PTP formation, we test cells ablated for g, OSCP and b subunits, and ρ(0) cells lac...

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Detalles Bibliográficos
Autores principales:	Carrer, Andrea, Tommasin, Ludovica, Šileikytė, Justina, Ciscato, Francesco, Filadi, Riccardo, Urbani, Andrea, Forte, Michael, Rasola, Andrea, Szabò, Ildikò, Carraro, Michela, Bernardi, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355262/ https://www.ncbi.nlm.nih.gov/pubmed/34376679 http://dx.doi.org/10.1038/s41467-021-25161-x

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