Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Engineered ectodomain trimer immunogens based on BG505 envelope glycoprotein are widely utilized as components of HIV vaccine development platforms. In this study, we used rhesus macaques to evaluate the immunogenicity of several stabilized BG505 SOSIP constructs both as free trimers and presented o...

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Detalles Bibliográficos
Autores principales: Antanasijevic, Aleksandar, Sewall, Leigh M., Cottrell, Christopher A., Carnathan, Diane G., Jimenez, Luis E., Ngo, Julia T., Silverman, Jennifer B., Groschel, Bettina, Georgeson, Erik, Bhiman, Jinal, Bastidas, Raiza, LaBranche, Celia, Allen, Joel D., Copps, Jeffrey, Perrett, Hailee R., Rantalainen, Kimmo, Cannac, Fabien, Yang, Yuhe R., de la Peña, Alba Torrents, Rocha, Rebeca Froes, Berndsen, Zachary T., Baker, David, King, Neil P., Sanders, Rogier W., Moore, John P., Crotty, Shane, Crispin, Max, Montefiori, David C., Burton, Dennis R., Schief, William R., Silvestri, Guido, Ward, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355326/
https://www.ncbi.nlm.nih.gov/pubmed/34376662
http://dx.doi.org/10.1038/s41467-021-25087-4

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