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Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder

There is ongoing debate about the similarities and differences between bipolar disorder (BD) and borderline personality disorder (BPD). Very few studies have concurrently assessed their neuropsychological profile and only on a narrow array of neuropsychological tests. We aimed to investigate the dif...

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Autores principales: Michopoulos, Ioannis, Tournikioti, Kalliopi, Paraschakis, Antonios, Karavia, Anna, Gournellis, Rossetos, Smyrnis, Nikolaos, Ferentinos, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355351/
https://www.ncbi.nlm.nih.gov/pubmed/34393854
http://dx.doi.org/10.3389/fpsyt.2021.690808
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author Michopoulos, Ioannis
Tournikioti, Kalliopi
Paraschakis, Antonios
Karavia, Anna
Gournellis, Rossetos
Smyrnis, Nikolaos
Ferentinos, Panagiotis
author_facet Michopoulos, Ioannis
Tournikioti, Kalliopi
Paraschakis, Antonios
Karavia, Anna
Gournellis, Rossetos
Smyrnis, Nikolaos
Ferentinos, Panagiotis
author_sort Michopoulos, Ioannis
collection PubMed
description There is ongoing debate about the similarities and differences between bipolar disorder (BD) and borderline personality disorder (BPD). Very few studies have concurrently assessed their neuropsychological profile and only on a narrow array of neuropsychological tests. We aimed to investigate the differences of these two patient groups on visual memory, executive function, and response inhibition. Twenty-nine BD patients, 27 BPD patients and 22 controls (all female) were directly compared on paired associates learning (PAL), set shifting (ID/ED), problem solving (SOC), and response inhibition (SSRT) using Cambridge Neuropsychological Test Automated Battery (CANTAB). Rank-normalized outcomes were contrasted in one-way ANOVA tests. Discriminant analysis was finally performed to predict BD or BPD patient status. BD patients performed significantly worse than controls on all tasks. BPD patients performed significantly worse than HC on all tests except SST. Significant differences between the two patient groups were recorded only on ID/ED, where BPD patients performed worse (p = 0.044). A forward stepwise discriminant analysis model based on ID/ED and SOC predicted correctly patients' group at 67.9% of cases. In conclusion, BD and BPD female patients appear to be more similar than different as regards their neuropsychological functions. This study is the first to show that BPD patients display more deficits than BD patients when directly compared on the set shifting executive function test, a marker of cognitive flexibility. Discerning BD from BPD patients through neuropsychological performance is promising but would improve by using additional subtler tests and psychometric evaluation.
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spelling pubmed-83553512021-08-12 Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder Michopoulos, Ioannis Tournikioti, Kalliopi Paraschakis, Antonios Karavia, Anna Gournellis, Rossetos Smyrnis, Nikolaos Ferentinos, Panagiotis Front Psychiatry Psychiatry There is ongoing debate about the similarities and differences between bipolar disorder (BD) and borderline personality disorder (BPD). Very few studies have concurrently assessed their neuropsychological profile and only on a narrow array of neuropsychological tests. We aimed to investigate the differences of these two patient groups on visual memory, executive function, and response inhibition. Twenty-nine BD patients, 27 BPD patients and 22 controls (all female) were directly compared on paired associates learning (PAL), set shifting (ID/ED), problem solving (SOC), and response inhibition (SSRT) using Cambridge Neuropsychological Test Automated Battery (CANTAB). Rank-normalized outcomes were contrasted in one-way ANOVA tests. Discriminant analysis was finally performed to predict BD or BPD patient status. BD patients performed significantly worse than controls on all tasks. BPD patients performed significantly worse than HC on all tests except SST. Significant differences between the two patient groups were recorded only on ID/ED, where BPD patients performed worse (p = 0.044). A forward stepwise discriminant analysis model based on ID/ED and SOC predicted correctly patients' group at 67.9% of cases. In conclusion, BD and BPD female patients appear to be more similar than different as regards their neuropsychological functions. This study is the first to show that BPD patients display more deficits than BD patients when directly compared on the set shifting executive function test, a marker of cognitive flexibility. Discerning BD from BPD patients through neuropsychological performance is promising but would improve by using additional subtler tests and psychometric evaluation. Frontiers Media S.A. 2021-07-28 /pmc/articles/PMC8355351/ /pubmed/34393854 http://dx.doi.org/10.3389/fpsyt.2021.690808 Text en Copyright © 2021 Michopoulos, Tournikioti, Paraschakis, Karavia, Gournellis, Smyrnis and Ferentinos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Michopoulos, Ioannis
Tournikioti, Kalliopi
Paraschakis, Antonios
Karavia, Anna
Gournellis, Rossetos
Smyrnis, Nikolaos
Ferentinos, Panagiotis
Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder
title Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder
title_full Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder
title_fullStr Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder
title_full_unstemmed Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder
title_short Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder
title_sort similar or different neuropsychological profiles? only set shifting differentiates women with bipolar vs. borderline personality disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355351/
https://www.ncbi.nlm.nih.gov/pubmed/34393854
http://dx.doi.org/10.3389/fpsyt.2021.690808
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