Cargando…
Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder
There is ongoing debate about the similarities and differences between bipolar disorder (BD) and borderline personality disorder (BPD). Very few studies have concurrently assessed their neuropsychological profile and only on a narrow array of neuropsychological tests. We aimed to investigate the dif...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355351/ https://www.ncbi.nlm.nih.gov/pubmed/34393854 http://dx.doi.org/10.3389/fpsyt.2021.690808 |
_version_ | 1783736744347172864 |
---|---|
author | Michopoulos, Ioannis Tournikioti, Kalliopi Paraschakis, Antonios Karavia, Anna Gournellis, Rossetos Smyrnis, Nikolaos Ferentinos, Panagiotis |
author_facet | Michopoulos, Ioannis Tournikioti, Kalliopi Paraschakis, Antonios Karavia, Anna Gournellis, Rossetos Smyrnis, Nikolaos Ferentinos, Panagiotis |
author_sort | Michopoulos, Ioannis |
collection | PubMed |
description | There is ongoing debate about the similarities and differences between bipolar disorder (BD) and borderline personality disorder (BPD). Very few studies have concurrently assessed their neuropsychological profile and only on a narrow array of neuropsychological tests. We aimed to investigate the differences of these two patient groups on visual memory, executive function, and response inhibition. Twenty-nine BD patients, 27 BPD patients and 22 controls (all female) were directly compared on paired associates learning (PAL), set shifting (ID/ED), problem solving (SOC), and response inhibition (SSRT) using Cambridge Neuropsychological Test Automated Battery (CANTAB). Rank-normalized outcomes were contrasted in one-way ANOVA tests. Discriminant analysis was finally performed to predict BD or BPD patient status. BD patients performed significantly worse than controls on all tasks. BPD patients performed significantly worse than HC on all tests except SST. Significant differences between the two patient groups were recorded only on ID/ED, where BPD patients performed worse (p = 0.044). A forward stepwise discriminant analysis model based on ID/ED and SOC predicted correctly patients' group at 67.9% of cases. In conclusion, BD and BPD female patients appear to be more similar than different as regards their neuropsychological functions. This study is the first to show that BPD patients display more deficits than BD patients when directly compared on the set shifting executive function test, a marker of cognitive flexibility. Discerning BD from BPD patients through neuropsychological performance is promising but would improve by using additional subtler tests and psychometric evaluation. |
format | Online Article Text |
id | pubmed-8355351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83553512021-08-12 Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder Michopoulos, Ioannis Tournikioti, Kalliopi Paraschakis, Antonios Karavia, Anna Gournellis, Rossetos Smyrnis, Nikolaos Ferentinos, Panagiotis Front Psychiatry Psychiatry There is ongoing debate about the similarities and differences between bipolar disorder (BD) and borderline personality disorder (BPD). Very few studies have concurrently assessed their neuropsychological profile and only on a narrow array of neuropsychological tests. We aimed to investigate the differences of these two patient groups on visual memory, executive function, and response inhibition. Twenty-nine BD patients, 27 BPD patients and 22 controls (all female) were directly compared on paired associates learning (PAL), set shifting (ID/ED), problem solving (SOC), and response inhibition (SSRT) using Cambridge Neuropsychological Test Automated Battery (CANTAB). Rank-normalized outcomes were contrasted in one-way ANOVA tests. Discriminant analysis was finally performed to predict BD or BPD patient status. BD patients performed significantly worse than controls on all tasks. BPD patients performed significantly worse than HC on all tests except SST. Significant differences between the two patient groups were recorded only on ID/ED, where BPD patients performed worse (p = 0.044). A forward stepwise discriminant analysis model based on ID/ED and SOC predicted correctly patients' group at 67.9% of cases. In conclusion, BD and BPD female patients appear to be more similar than different as regards their neuropsychological functions. This study is the first to show that BPD patients display more deficits than BD patients when directly compared on the set shifting executive function test, a marker of cognitive flexibility. Discerning BD from BPD patients through neuropsychological performance is promising but would improve by using additional subtler tests and psychometric evaluation. Frontiers Media S.A. 2021-07-28 /pmc/articles/PMC8355351/ /pubmed/34393854 http://dx.doi.org/10.3389/fpsyt.2021.690808 Text en Copyright © 2021 Michopoulos, Tournikioti, Paraschakis, Karavia, Gournellis, Smyrnis and Ferentinos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Michopoulos, Ioannis Tournikioti, Kalliopi Paraschakis, Antonios Karavia, Anna Gournellis, Rossetos Smyrnis, Nikolaos Ferentinos, Panagiotis Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder |
title | Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder |
title_full | Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder |
title_fullStr | Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder |
title_full_unstemmed | Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder |
title_short | Similar or Different Neuropsychological Profiles? Only Set Shifting Differentiates Women With Bipolar vs. Borderline Personality Disorder |
title_sort | similar or different neuropsychological profiles? only set shifting differentiates women with bipolar vs. borderline personality disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355351/ https://www.ncbi.nlm.nih.gov/pubmed/34393854 http://dx.doi.org/10.3389/fpsyt.2021.690808 |
work_keys_str_mv | AT michopoulosioannis similarordifferentneuropsychologicalprofilesonlysetshiftingdifferentiateswomenwithbipolarvsborderlinepersonalitydisorder AT tournikiotikalliopi similarordifferentneuropsychologicalprofilesonlysetshiftingdifferentiateswomenwithbipolarvsborderlinepersonalitydisorder AT paraschakisantonios similarordifferentneuropsychologicalprofilesonlysetshiftingdifferentiateswomenwithbipolarvsborderlinepersonalitydisorder AT karaviaanna similarordifferentneuropsychologicalprofilesonlysetshiftingdifferentiateswomenwithbipolarvsborderlinepersonalitydisorder AT gournellisrossetos similarordifferentneuropsychologicalprofilesonlysetshiftingdifferentiateswomenwithbipolarvsborderlinepersonalitydisorder AT smyrnisnikolaos similarordifferentneuropsychologicalprofilesonlysetshiftingdifferentiateswomenwithbipolarvsborderlinepersonalitydisorder AT ferentinospanagiotis similarordifferentneuropsychologicalprofilesonlysetshiftingdifferentiateswomenwithbipolarvsborderlinepersonalitydisorder |