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Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases
Impaired energy homeostasis and aberrant translational control have independently been implicated in the pathogenesis of neurodegenerative diseases. AMP kinase (AMPK), regulated by the ratio of cellular AMP and ATP, is a major gatekeeper for cellular energy homeostasis. Abnormal regulation of AMPK h...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355359/ https://www.ncbi.nlm.nih.gov/pubmed/34393724 http://dx.doi.org/10.3389/fncel.2021.668500 |
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author | Liu, Yu-Ju Chern, Yijuang |
author_facet | Liu, Yu-Ju Chern, Yijuang |
author_sort | Liu, Yu-Ju |
collection | PubMed |
description | Impaired energy homeostasis and aberrant translational control have independently been implicated in the pathogenesis of neurodegenerative diseases. AMP kinase (AMPK), regulated by the ratio of cellular AMP and ATP, is a major gatekeeper for cellular energy homeostasis. Abnormal regulation of AMPK has been reported in several neurodegenerative diseases, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). Most importantly, AMPK activation is known to suppress the translational machinery by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1), activating translational regulators, and phosphorylating nuclear transporter factors. In this review, we describe recent findings on the emerging role of protein translation impairment caused by energy dysregulation in neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-8355359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83553592021-08-12 Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases Liu, Yu-Ju Chern, Yijuang Front Cell Neurosci Cellular Neuroscience Impaired energy homeostasis and aberrant translational control have independently been implicated in the pathogenesis of neurodegenerative diseases. AMP kinase (AMPK), regulated by the ratio of cellular AMP and ATP, is a major gatekeeper for cellular energy homeostasis. Abnormal regulation of AMPK has been reported in several neurodegenerative diseases, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). Most importantly, AMPK activation is known to suppress the translational machinery by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1), activating translational regulators, and phosphorylating nuclear transporter factors. In this review, we describe recent findings on the emerging role of protein translation impairment caused by energy dysregulation in neurodegenerative diseases. Frontiers Media S.A. 2021-07-28 /pmc/articles/PMC8355359/ /pubmed/34393724 http://dx.doi.org/10.3389/fncel.2021.668500 Text en Copyright © 2021 Liu and Chern. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Liu, Yu-Ju Chern, Yijuang Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases |
title | Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases |
title_full | Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases |
title_fullStr | Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases |
title_full_unstemmed | Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases |
title_short | Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases |
title_sort | contribution of energy dysfunction to impaired protein translation in neurodegenerative diseases |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355359/ https://www.ncbi.nlm.nih.gov/pubmed/34393724 http://dx.doi.org/10.3389/fncel.2021.668500 |
work_keys_str_mv | AT liuyuju contributionofenergydysfunctiontoimpairedproteintranslationinneurodegenerativediseases AT chernyijuang contributionofenergydysfunctiontoimpairedproteintranslationinneurodegenerativediseases |