A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome

We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 4...

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Detalles Bibliográficos
Autores principales: Tsukada, Akinari, Suzuki, Manabu, Kishino, Yuya, Misumi, Kento, Igari, Toru, Nakajima, Noriko, Sato, Yuko, Suzuki, Tadaki, Katsuno, Takashi, Kusaba, Yusaku, Tsujimoto, Yoshie, Sakamoto, Keita, Hashimoto, Masao, Terada, Junko, Takasaki, Jin, Izumi, Shinyu, Hojo, Masayuki, Sugiyama, Haruhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355385/
https://www.ncbi.nlm.nih.gov/pubmed/34053986
http://dx.doi.org/10.2169/internalmedicine.7089-21
Descripción
Sumario:We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-positive cells were detected in the lung, suggesting delayed virus clearance owing to his long-term immunosuppressed state, leading to constant lung damage and ultimately respiratory failure.

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