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A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome

We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 4...

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Autores principales: Tsukada, Akinari, Suzuki, Manabu, Kishino, Yuya, Misumi, Kento, Igari, Toru, Nakajima, Noriko, Sato, Yuko, Suzuki, Tadaki, Katsuno, Takashi, Kusaba, Yusaku, Tsujimoto, Yoshie, Sakamoto, Keita, Hashimoto, Masao, Terada, Junko, Takasaki, Jin, Izumi, Shinyu, Hojo, Masayuki, Sugiyama, Haruhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355385/
https://www.ncbi.nlm.nih.gov/pubmed/34053986
http://dx.doi.org/10.2169/internalmedicine.7089-21
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author Tsukada, Akinari
Suzuki, Manabu
Kishino, Yuya
Misumi, Kento
Igari, Toru
Nakajima, Noriko
Sato, Yuko
Suzuki, Tadaki
Katsuno, Takashi
Kusaba, Yusaku
Tsujimoto, Yoshie
Sakamoto, Keita
Hashimoto, Masao
Terada, Junko
Takasaki, Jin
Izumi, Shinyu
Hojo, Masayuki
Sugiyama, Haruhito
author_facet Tsukada, Akinari
Suzuki, Manabu
Kishino, Yuya
Misumi, Kento
Igari, Toru
Nakajima, Noriko
Sato, Yuko
Suzuki, Tadaki
Katsuno, Takashi
Kusaba, Yusaku
Tsujimoto, Yoshie
Sakamoto, Keita
Hashimoto, Masao
Terada, Junko
Takasaki, Jin
Izumi, Shinyu
Hojo, Masayuki
Sugiyama, Haruhito
author_sort Tsukada, Akinari
collection PubMed
description We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-positive cells were detected in the lung, suggesting delayed virus clearance owing to his long-term immunosuppressed state, leading to constant lung damage and ultimately respiratory failure.
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spelling pubmed-83553852021-08-24 A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome Tsukada, Akinari Suzuki, Manabu Kishino, Yuya Misumi, Kento Igari, Toru Nakajima, Noriko Sato, Yuko Suzuki, Tadaki Katsuno, Takashi Kusaba, Yusaku Tsujimoto, Yoshie Sakamoto, Keita Hashimoto, Masao Terada, Junko Takasaki, Jin Izumi, Shinyu Hojo, Masayuki Sugiyama, Haruhito Intern Med Case Report We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-positive cells were detected in the lung, suggesting delayed virus clearance owing to his long-term immunosuppressed state, leading to constant lung damage and ultimately respiratory failure. The Japanese Society of Internal Medicine 2021-05-29 2021-07-15 /pmc/articles/PMC8355385/ /pubmed/34053986 http://dx.doi.org/10.2169/internalmedicine.7089-21 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tsukada, Akinari
Suzuki, Manabu
Kishino, Yuya
Misumi, Kento
Igari, Toru
Nakajima, Noriko
Sato, Yuko
Suzuki, Tadaki
Katsuno, Takashi
Kusaba, Yusaku
Tsujimoto, Yoshie
Sakamoto, Keita
Hashimoto, Masao
Terada, Junko
Takasaki, Jin
Izumi, Shinyu
Hojo, Masayuki
Sugiyama, Haruhito
A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome
title A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome
title_full A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome
title_fullStr A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome
title_full_unstemmed A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome
title_short A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome
title_sort kidney transplant patient who died of covid-19-associated severe acute respiratory distress syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355385/
https://www.ncbi.nlm.nih.gov/pubmed/34053986
http://dx.doi.org/10.2169/internalmedicine.7089-21
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