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Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome
A 48-year-old woman presented with a fever, microscopic hematuria, proteinuria, and rapid deterioration of the renal function. Pulmonary alveolar hemorrhaging and a high level of anti-glomerular basement membrane (GBM) antibodies (700 IU/mL) were observed. Based on her medical history and positive f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Internal Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355402/ https://www.ncbi.nlm.nih.gov/pubmed/33612667 http://dx.doi.org/10.2169/internalmedicine.4943-20 |
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author | Torigoe, Miki Obata, Yoko Kitamura, Mineaki Hara, Shigeo Fukuoka, Junya Nishino, Tomoya |
author_facet | Torigoe, Miki Obata, Yoko Kitamura, Mineaki Hara, Shigeo Fukuoka, Junya Nishino, Tomoya |
author_sort | Torigoe, Miki |
collection | PubMed |
description | A 48-year-old woman presented with a fever, microscopic hematuria, proteinuria, and rapid deterioration of the renal function. Pulmonary alveolar hemorrhaging and a high level of anti-glomerular basement membrane (GBM) antibodies (700 IU/mL) were observed. Based on her medical history and positive findings of serum lupus anticoagulant, anti-phospholipid antibody syndrome (APS) was suspected. A renal biopsy revealed cellular crescentic glomerulonephritis with thrombosis, suggesting anti-GBM disease with catastrophic APS. The patient was treated with pulse steroid therapy, plasma exchange, hemodialysis, and intravenous cyclophosphamide pulse therapy. To our knowledge, this is the first report of a patient with anti-GBM disease and APS. |
format | Online Article Text |
id | pubmed-8355402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-83554022021-08-24 Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome Torigoe, Miki Obata, Yoko Kitamura, Mineaki Hara, Shigeo Fukuoka, Junya Nishino, Tomoya Intern Med Case Report A 48-year-old woman presented with a fever, microscopic hematuria, proteinuria, and rapid deterioration of the renal function. Pulmonary alveolar hemorrhaging and a high level of anti-glomerular basement membrane (GBM) antibodies (700 IU/mL) were observed. Based on her medical history and positive findings of serum lupus anticoagulant, anti-phospholipid antibody syndrome (APS) was suspected. A renal biopsy revealed cellular crescentic glomerulonephritis with thrombosis, suggesting anti-GBM disease with catastrophic APS. The patient was treated with pulse steroid therapy, plasma exchange, hemodialysis, and intravenous cyclophosphamide pulse therapy. To our knowledge, this is the first report of a patient with anti-GBM disease and APS. The Japanese Society of Internal Medicine 2021-02-22 2021-07-15 /pmc/articles/PMC8355402/ /pubmed/33612667 http://dx.doi.org/10.2169/internalmedicine.4943-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Torigoe, Miki Obata, Yoko Kitamura, Mineaki Hara, Shigeo Fukuoka, Junya Nishino, Tomoya Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome |
title | Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome |
title_full | Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome |
title_fullStr | Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome |
title_full_unstemmed | Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome |
title_short | Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome |
title_sort | anti-glomerular basement membrane disease with antiphospholipid syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355402/ https://www.ncbi.nlm.nih.gov/pubmed/33612667 http://dx.doi.org/10.2169/internalmedicine.4943-20 |
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