Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Staphylococcus aureus Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia

A pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR)-based testing protocol with a 70% acceptance rate for vancomycin discontinuation within 24 hours of negative results significantly reduced unnecessary vancomycin use with an estimated cost av...

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Autores principales: Meng, L, Pourali, S, Hitchcock, M M, Ha, D R, Mui, E, Alegria, W, Fox, E, Diep, C, Swayngim, R, Chang, A, Banaei, N, Deresinski, S, Holubar, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355456/
https://www.ncbi.nlm.nih.gov/pubmed/34386545
http://dx.doi.org/10.1093/ofid/ofab099
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author Meng, L
Pourali, S
Hitchcock, M M
Ha, D R
Mui, E
Alegria, W
Fox, E
Diep, C
Swayngim, R
Chang, A
Banaei, N
Deresinski, S
Holubar, M
author_facet Meng, L
Pourali, S
Hitchcock, M M
Ha, D R
Mui, E
Alegria, W
Fox, E
Diep, C
Swayngim, R
Chang, A
Banaei, N
Deresinski, S
Holubar, M
author_sort Meng, L
collection PubMed
description A pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR)-based testing protocol with a 70% acceptance rate for vancomycin discontinuation within 24 hours of negative results significantly reduced unnecessary vancomycin use with an estimated cost avoidance of $40 per vancomycin course. We found high concordance (141 of 147, 96%) of culture-based versus PCR-based MRSA nasal screening.
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spelling pubmed-83554562021-08-11 Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Staphylococcus aureus Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia Meng, L Pourali, S Hitchcock, M M Ha, D R Mui, E Alegria, W Fox, E Diep, C Swayngim, R Chang, A Banaei, N Deresinski, S Holubar, M Open Forum Infect Dis Brief Reports A pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR)-based testing protocol with a 70% acceptance rate for vancomycin discontinuation within 24 hours of negative results significantly reduced unnecessary vancomycin use with an estimated cost avoidance of $40 per vancomycin course. We found high concordance (141 of 147, 96%) of culture-based versus PCR-based MRSA nasal screening. Oxford University Press 2021-03-04 /pmc/articles/PMC8355456/ /pubmed/34386545 http://dx.doi.org/10.1093/ofid/ofab099 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Meng, L
Pourali, S
Hitchcock, M M
Ha, D R
Mui, E
Alegria, W
Fox, E
Diep, C
Swayngim, R
Chang, A
Banaei, N
Deresinski, S
Holubar, M
Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Staphylococcus aureus Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia
title Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Staphylococcus aureus Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia
title_full Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Staphylococcus aureus Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia
title_fullStr Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Staphylococcus aureus Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia
title_full_unstemmed Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Staphylococcus aureus Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia
title_short Discontinuation Patterns and Cost Avoidance of a Pharmacist-Driven Methicillin-Resistant Staphylococcus aureus Nasal Polymerase Chain Reaction Testing Protocol for De-escalation of Empiric Vancomycin for Suspected Pneumonia
title_sort discontinuation patterns and cost avoidance of a pharmacist-driven methicillin-resistant staphylococcus aureus nasal polymerase chain reaction testing protocol for de-escalation of empiric vancomycin for suspected pneumonia
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355456/
https://www.ncbi.nlm.nih.gov/pubmed/34386545
http://dx.doi.org/10.1093/ofid/ofab099
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