Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection

BACKGROUND: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. METHODS: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome seq...

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Autores principales: Sherman, Amy C, Lu, Xiaoyan, Schneider, Eileen, Langston, Amelia, Ellis, Carla L, Pastan, Stephen, Bhatnagar, Julu, Reagan-Steiner, Sarah, Annambhotla, Pallavi, Lindstrom, Stephen, Mehta, Aneesh, Pouch, Stephanie M, Sexton, Marybeth E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Novel ID Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355461/
https://www.ncbi.nlm.nih.gov/pubmed/34386544
http://dx.doi.org/10.1093/ofid/ofab092
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author Sherman, Amy C
Lu, Xiaoyan
Schneider, Eileen
Langston, Amelia
Ellis, Carla L
Pastan, Stephen
Bhatnagar, Julu
Reagan-Steiner, Sarah
Annambhotla, Pallavi
Lindstrom, Stephen
Mehta, Aneesh
Pouch, Stephanie M
Sexton, Marybeth E
author_facet Sherman, Amy C
Lu, Xiaoyan
Schneider, Eileen
Langston, Amelia
Ellis, Carla L
Pastan, Stephen
Bhatnagar, Julu
Reagan-Steiner, Sarah
Annambhotla, Pallavi
Lindstrom, Stephen
Mehta, Aneesh
Pouch, Stephanie M
Sexton, Marybeth E
author_sort Sherman, Amy C
collection PubMed
description BACKGROUND: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. METHODS: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. RESULTS: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. CONCLUSIONS: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.
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spelling pubmed-83554612021-08-11 Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection Sherman, Amy C Lu, Xiaoyan Schneider, Eileen Langston, Amelia Ellis, Carla L Pastan, Stephen Bhatnagar, Julu Reagan-Steiner, Sarah Annambhotla, Pallavi Lindstrom, Stephen Mehta, Aneesh Pouch, Stephanie M Sexton, Marybeth E Open Forum Infect Dis Novel ID Cases BACKGROUND: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. METHODS: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. RESULTS: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. CONCLUSIONS: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options. Oxford University Press 2021-02-25 /pmc/articles/PMC8355461/ /pubmed/34386544 http://dx.doi.org/10.1093/ofid/ofab092 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Novel ID Cases
Sherman, Amy C
Lu, Xiaoyan
Schneider, Eileen
Langston, Amelia
Ellis, Carla L
Pastan, Stephen
Bhatnagar, Julu
Reagan-Steiner, Sarah
Annambhotla, Pallavi
Lindstrom, Stephen
Mehta, Aneesh
Pouch, Stephanie M
Sexton, Marybeth E
Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection
title Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection
title_full Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection
title_fullStr Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection
title_full_unstemmed Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection
title_short Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection
title_sort human adenovirus 11 in 2 renal transplant recipients: suspected donor-derived infection
topic Novel ID Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355461/
https://www.ncbi.nlm.nih.gov/pubmed/34386544
http://dx.doi.org/10.1093/ofid/ofab092
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