Optimization and biological validation of an in vitro assay using the transfected Dm28c/pLacZ Trypanosoma cruzi strain

There is an urgent need to develop safer and more effective drugs for Chagas disease, as the current treatment relies on benznidazole (BZ) and nifurtimox (NFX). Using the Trypanosoma cruzi Dm28c strain genetically engineered to express the Escherichia coli β-galactosidase gene, lacZ, we have adapted...

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Detalles Bibliográficos
Autores principales: Gulin, Julián Ernesto Nicolás, Rocco, Daniela Marisa, Alonso, Victoria, Cribb, Pamela, Altcheh, Jaime, García-Bournissen, Facundo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Methods Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355463/
https://www.ncbi.nlm.nih.gov/pubmed/34386588
http://dx.doi.org/10.1093/biomethods/bpab004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355463/
https://www.ncbi.nlm.nih.gov/pubmed/34386588
http://dx.doi.org/10.1093/biomethods/bpab004

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