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Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events

Our knowledge about people can help us predict how they will behave in particular situations and interpret their actions. In this study, we investigated the cognitive and neural effects of person knowledge on the encoding and retrieval of novel life-like events. Healthy human participants learnt abo...

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Detalles Bibliográficos
Autores principales: Raykov, Petar P, Keidel, James L, Oakhill, Jane, Bird, Chris M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355471/
https://www.ncbi.nlm.nih.gov/pubmed/33866362
http://dx.doi.org/10.1093/cercor/bhab027
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author Raykov, Petar P
Keidel, James L
Oakhill, Jane
Bird, Chris M
author_facet Raykov, Petar P
Keidel, James L
Oakhill, Jane
Bird, Chris M
author_sort Raykov, Petar P
collection PubMed
description Our knowledge about people can help us predict how they will behave in particular situations and interpret their actions. In this study, we investigated the cognitive and neural effects of person knowledge on the encoding and retrieval of novel life-like events. Healthy human participants learnt about two characters over a week by watching 6 episodes of one of two situation comedies, which were both centered on a young couple. In the scanner, they watched and then silently recalled 20 new scenes from both shows that were all set in unfamiliar locations: 10 from their trained show and 10 from the untrained show. After scanning, participants’ recognition memory was better for scenes from the trained show. The functional magnetic resonance imaging (fMRI) patterns of brain activity when watching the videos were reinstated during recall, but this effect was not modulated by training. However, person knowledge boosted the similarity in fMRI patterns of activity in the medial prefrontal cortex (MPFC) when watching the new events involving familiar characters. Our findings identify a role for the MPFC in the representation of schematic person knowledge during the encoding of novel, lifelike events.
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spelling pubmed-83554712021-08-11 Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events Raykov, Petar P Keidel, James L Oakhill, Jane Bird, Chris M Cereb Cortex Original Article Our knowledge about people can help us predict how they will behave in particular situations and interpret their actions. In this study, we investigated the cognitive and neural effects of person knowledge on the encoding and retrieval of novel life-like events. Healthy human participants learnt about two characters over a week by watching 6 episodes of one of two situation comedies, which were both centered on a young couple. In the scanner, they watched and then silently recalled 20 new scenes from both shows that were all set in unfamiliar locations: 10 from their trained show and 10 from the untrained show. After scanning, participants’ recognition memory was better for scenes from the trained show. The functional magnetic resonance imaging (fMRI) patterns of brain activity when watching the videos were reinstated during recall, but this effect was not modulated by training. However, person knowledge boosted the similarity in fMRI patterns of activity in the medial prefrontal cortex (MPFC) when watching the new events involving familiar characters. Our findings identify a role for the MPFC in the representation of schematic person knowledge during the encoding of novel, lifelike events. Oxford University Press 2021-04-19 /pmc/articles/PMC8355471/ /pubmed/33866362 http://dx.doi.org/10.1093/cercor/bhab027 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Raykov, Petar P
Keidel, James L
Oakhill, Jane
Bird, Chris M
Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events
title Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events
title_full Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events
title_fullStr Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events
title_full_unstemmed Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events
title_short Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of New Lifelike Events
title_sort activation of person knowledge in medial prefrontal cortex during the encoding of new lifelike events
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355471/
https://www.ncbi.nlm.nih.gov/pubmed/33866362
http://dx.doi.org/10.1093/cercor/bhab027
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