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Role of the Bone Marrow Niche in Supporting the Pathogenesis of Lymphoid Malignancies

While the bone marrow (BM) microenvironment is the primary location for nurturing the multipotent hematopoietic stem cells and developing the blood cells of either myeloid or lymphoid origin under normal physiological conditions, it could provide a supportive milieu for the proliferation of blood ca...

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Detalles Bibliográficos
Autores principales: Jalali, Shahrzad, Ansell, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355623/
https://www.ncbi.nlm.nih.gov/pubmed/34395425
http://dx.doi.org/10.3389/fcell.2021.692320
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author Jalali, Shahrzad
Ansell, Stephen M.
author_facet Jalali, Shahrzad
Ansell, Stephen M.
author_sort Jalali, Shahrzad
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description While the bone marrow (BM) microenvironment is the primary location for nurturing the multipotent hematopoietic stem cells and developing the blood cells of either myeloid or lymphoid origin under normal physiological conditions, it could provide a supportive milieu for the proliferation of blood cancer cells. In fact, the multiple and complex direct cell-to-cell or indirect soluble factors-mediated interactions taking place among the BM cells of different origins are shown to play a significant role in tumorigenesis of hematological cancers. In the current review, we focus on lymphoid malignancies and highlight the novel insights surrounding the role of both cellular as well as non-cellular BM compartments in modulating hematopoiesis and promoting growth and proliferation of cancer cells across a variety of aggressive and indolent lymphoid malignancies, including diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and Waldenstrom Macroglobulinemia. We also discuss the mechanisms of potential intervention and discuss their therapeutic impact in clinical settings.
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spelling pubmed-83556232021-08-12 Role of the Bone Marrow Niche in Supporting the Pathogenesis of Lymphoid Malignancies Jalali, Shahrzad Ansell, Stephen M. Front Cell Dev Biol Cell and Developmental Biology While the bone marrow (BM) microenvironment is the primary location for nurturing the multipotent hematopoietic stem cells and developing the blood cells of either myeloid or lymphoid origin under normal physiological conditions, it could provide a supportive milieu for the proliferation of blood cancer cells. In fact, the multiple and complex direct cell-to-cell or indirect soluble factors-mediated interactions taking place among the BM cells of different origins are shown to play a significant role in tumorigenesis of hematological cancers. In the current review, we focus on lymphoid malignancies and highlight the novel insights surrounding the role of both cellular as well as non-cellular BM compartments in modulating hematopoiesis and promoting growth and proliferation of cancer cells across a variety of aggressive and indolent lymphoid malignancies, including diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and Waldenstrom Macroglobulinemia. We also discuss the mechanisms of potential intervention and discuss their therapeutic impact in clinical settings. Frontiers Media S.A. 2021-07-28 /pmc/articles/PMC8355623/ /pubmed/34395425 http://dx.doi.org/10.3389/fcell.2021.692320 Text en Copyright © 2021 Jalali and Ansell. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Jalali, Shahrzad
Ansell, Stephen M.
Role of the Bone Marrow Niche in Supporting the Pathogenesis of Lymphoid Malignancies
title Role of the Bone Marrow Niche in Supporting the Pathogenesis of Lymphoid Malignancies
title_full Role of the Bone Marrow Niche in Supporting the Pathogenesis of Lymphoid Malignancies
title_fullStr Role of the Bone Marrow Niche in Supporting the Pathogenesis of Lymphoid Malignancies
title_full_unstemmed Role of the Bone Marrow Niche in Supporting the Pathogenesis of Lymphoid Malignancies
title_short Role of the Bone Marrow Niche in Supporting the Pathogenesis of Lymphoid Malignancies
title_sort role of the bone marrow niche in supporting the pathogenesis of lymphoid malignancies
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355623/
https://www.ncbi.nlm.nih.gov/pubmed/34395425
http://dx.doi.org/10.3389/fcell.2021.692320
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