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Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice
The environment of an organism can convey a powerful influence over its biology. Environmental enrichment (EE), as a eustress model, has been used extensively in neuroscience to study neurogenesis and brain plasticity. EE has also been used as an intervention for the treatment and prevention of neur...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355812/ https://www.ncbi.nlm.nih.gov/pubmed/34394087 http://dx.doi.org/10.3389/fimmu.2021.695859 |
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author | Xiao, Run Ali, Seemaab Caligiuri, Michael A. Cao, Lei |
author_facet | Xiao, Run Ali, Seemaab Caligiuri, Michael A. Cao, Lei |
author_sort | Xiao, Run |
collection | PubMed |
description | The environment of an organism can convey a powerful influence over its biology. Environmental enrichment (EE), as a eustress model, has been used extensively in neuroscience to study neurogenesis and brain plasticity. EE has also been used as an intervention for the treatment and prevention of neurological and psychiatric disorders with limited clinical application. By contrast, the effects of EE on the immune system are relatively less investigated. Recently, accumulating evidence has demonstrated that EE can robustly impact immune function. In this review, we summarize the major components of EE, the impact of EE on natural killer (NK) cells, EE’s immunoprotective roles in cancer, and the underlying mechanisms of EE-induced NK cell regulation. Moreover, we discuss opportunities for translational application based on insights from animal research of EE-induced NK cell regulation. |
format | Online Article Text |
id | pubmed-8355812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83558122021-08-12 Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice Xiao, Run Ali, Seemaab Caligiuri, Michael A. Cao, Lei Front Immunol Immunology The environment of an organism can convey a powerful influence over its biology. Environmental enrichment (EE), as a eustress model, has been used extensively in neuroscience to study neurogenesis and brain plasticity. EE has also been used as an intervention for the treatment and prevention of neurological and psychiatric disorders with limited clinical application. By contrast, the effects of EE on the immune system are relatively less investigated. Recently, accumulating evidence has demonstrated that EE can robustly impact immune function. In this review, we summarize the major components of EE, the impact of EE on natural killer (NK) cells, EE’s immunoprotective roles in cancer, and the underlying mechanisms of EE-induced NK cell regulation. Moreover, we discuss opportunities for translational application based on insights from animal research of EE-induced NK cell regulation. Frontiers Media S.A. 2021-07-28 /pmc/articles/PMC8355812/ /pubmed/34394087 http://dx.doi.org/10.3389/fimmu.2021.695859 Text en Copyright © 2021 Xiao, Ali, Caligiuri and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Xiao, Run Ali, Seemaab Caligiuri, Michael A. Cao, Lei Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice |
title | Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice |
title_full | Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice |
title_fullStr | Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice |
title_full_unstemmed | Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice |
title_short | Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice |
title_sort | enhancing effects of environmental enrichment on the functions of natural killer cells in mice |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355812/ https://www.ncbi.nlm.nih.gov/pubmed/34394087 http://dx.doi.org/10.3389/fimmu.2021.695859 |
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