Cargando…

Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice

The environment of an organism can convey a powerful influence over its biology. Environmental enrichment (EE), as a eustress model, has been used extensively in neuroscience to study neurogenesis and brain plasticity. EE has also been used as an intervention for the treatment and prevention of neur...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Run, Ali, Seemaab, Caligiuri, Michael A., Cao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355812/
https://www.ncbi.nlm.nih.gov/pubmed/34394087
http://dx.doi.org/10.3389/fimmu.2021.695859
_version_ 1783736826877444096
author Xiao, Run
Ali, Seemaab
Caligiuri, Michael A.
Cao, Lei
author_facet Xiao, Run
Ali, Seemaab
Caligiuri, Michael A.
Cao, Lei
author_sort Xiao, Run
collection PubMed
description The environment of an organism can convey a powerful influence over its biology. Environmental enrichment (EE), as a eustress model, has been used extensively in neuroscience to study neurogenesis and brain plasticity. EE has also been used as an intervention for the treatment and prevention of neurological and psychiatric disorders with limited clinical application. By contrast, the effects of EE on the immune system are relatively less investigated. Recently, accumulating evidence has demonstrated that EE can robustly impact immune function. In this review, we summarize the major components of EE, the impact of EE on natural killer (NK) cells, EE’s immunoprotective roles in cancer, and the underlying mechanisms of EE-induced NK cell regulation. Moreover, we discuss opportunities for translational application based on insights from animal research of EE-induced NK cell regulation.
format Online
Article
Text
id pubmed-8355812
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83558122021-08-12 Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice Xiao, Run Ali, Seemaab Caligiuri, Michael A. Cao, Lei Front Immunol Immunology The environment of an organism can convey a powerful influence over its biology. Environmental enrichment (EE), as a eustress model, has been used extensively in neuroscience to study neurogenesis and brain plasticity. EE has also been used as an intervention for the treatment and prevention of neurological and psychiatric disorders with limited clinical application. By contrast, the effects of EE on the immune system are relatively less investigated. Recently, accumulating evidence has demonstrated that EE can robustly impact immune function. In this review, we summarize the major components of EE, the impact of EE on natural killer (NK) cells, EE’s immunoprotective roles in cancer, and the underlying mechanisms of EE-induced NK cell regulation. Moreover, we discuss opportunities for translational application based on insights from animal research of EE-induced NK cell regulation. Frontiers Media S.A. 2021-07-28 /pmc/articles/PMC8355812/ /pubmed/34394087 http://dx.doi.org/10.3389/fimmu.2021.695859 Text en Copyright © 2021 Xiao, Ali, Caligiuri and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xiao, Run
Ali, Seemaab
Caligiuri, Michael A.
Cao, Lei
Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice
title Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice
title_full Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice
title_fullStr Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice
title_full_unstemmed Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice
title_short Enhancing Effects of Environmental Enrichment on the Functions of Natural Killer Cells in Mice
title_sort enhancing effects of environmental enrichment on the functions of natural killer cells in mice
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355812/
https://www.ncbi.nlm.nih.gov/pubmed/34394087
http://dx.doi.org/10.3389/fimmu.2021.695859
work_keys_str_mv AT xiaorun enhancingeffectsofenvironmentalenrichmentonthefunctionsofnaturalkillercellsinmice
AT aliseemaab enhancingeffectsofenvironmentalenrichmentonthefunctionsofnaturalkillercellsinmice
AT caligiurimichaela enhancingeffectsofenvironmentalenrichmentonthefunctionsofnaturalkillercellsinmice
AT caolei enhancingeffectsofenvironmentalenrichmentonthefunctionsofnaturalkillercellsinmice