Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

Upon infection, Mycobacterium leprae, an obligate intracellular bacillus, induces accumulation of cholesterol-enriched lipid droplets (LDs) in Schwann cells (SCs). LDs are promptly recruited to M. leprae-containing phagosomes, and inhibition of this process decreases bacterial survival, suggesting t...

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Detalles Bibliográficos
Autores principales: Rosa, Thabatta L. S. A., Marques, Maria Angela M., DeBoard, Zachary, Hutchins, Kelly, Silva, Carlos Adriano A., Montague, Christine R., Yuan, Tianao, Amaral, Julio J., Atella, Georgia C., Rosa, Patrícia S., Mattos, Katherine A., VanderVen, Brian C., Lahiri, Ramanuj, Sampson, Nicole S., Brennan, Patrick J., Belisle, John T., Pessolani, Maria Cristina V., Berrêdo-Pinho, Marcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355898/
https://www.ncbi.nlm.nih.gov/pubmed/34395315
http://dx.doi.org/10.3389/fcimb.2021.709972

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