Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential

Recent progress has been made in understanding the roles and mechanisms of endoplasmic reticulum (ER) stress in the development and pathogenesis of diabetic nephropathy (DN). Hyperglycemia induces ER stress and apoptosis in renal cells. The induction of ER stress can be cytoprotective or cytotoxic....

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Detalles Bibliográficos
Autores principales: Ni, Lihua, Yuan, Cheng, Wu, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355967/
https://www.ncbi.nlm.nih.gov/pubmed/34394833
http://dx.doi.org/10.1155/2021/7277966
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author Ni, Lihua
Yuan, Cheng
Wu, Xiaoyan
author_facet Ni, Lihua
Yuan, Cheng
Wu, Xiaoyan
author_sort Ni, Lihua
collection PubMed
description Recent progress has been made in understanding the roles and mechanisms of endoplasmic reticulum (ER) stress in the development and pathogenesis of diabetic nephropathy (DN). Hyperglycemia induces ER stress and apoptosis in renal cells. The induction of ER stress can be cytoprotective or cytotoxic. Experimental treatment of animals with ER stress inhibitors alleviated renal damage. Considering these findings, the normalization of ER stress by pharmacological agents is a promising approach to prevent or arrest DN progression. The current article reviews the mechanisms, roles, and therapeutic aspects of these findings.
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spelling pubmed-83559672021-08-12 Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential Ni, Lihua Yuan, Cheng Wu, Xiaoyan Oxid Med Cell Longev Review Article Recent progress has been made in understanding the roles and mechanisms of endoplasmic reticulum (ER) stress in the development and pathogenesis of diabetic nephropathy (DN). Hyperglycemia induces ER stress and apoptosis in renal cells. The induction of ER stress can be cytoprotective or cytotoxic. Experimental treatment of animals with ER stress inhibitors alleviated renal damage. Considering these findings, the normalization of ER stress by pharmacological agents is a promising approach to prevent or arrest DN progression. The current article reviews the mechanisms, roles, and therapeutic aspects of these findings. Hindawi 2021-08-02 /pmc/articles/PMC8355967/ /pubmed/34394833 http://dx.doi.org/10.1155/2021/7277966 Text en Copyright © 2021 Lihua Ni et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ni, Lihua
Yuan, Cheng
Wu, Xiaoyan
Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential
title Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential
title_full Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential
title_fullStr Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential
title_full_unstemmed Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential
title_short Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential
title_sort endoplasmic reticulum stress in diabetic nephrology: regulation, pathological role, and therapeutic potential
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355967/
https://www.ncbi.nlm.nih.gov/pubmed/34394833
http://dx.doi.org/10.1155/2021/7277966
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