Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets

RESULTS: Prolonged exposure to palmitate increased the expression of ACE and AngII type 1 receptor (ATR1) and decreased the ACE2 expression, which was partly offset by berberine. In ob/ob mice, berberine increased in tolerance to glucose, improved abnormal β-cell and α-cell distributions, upregulate...

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Autores principales: Huang, Chenghu, Lei, Pan, Peng, Caibi, Li, Min, Guo, Yifei, Li, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356011/
https://www.ncbi.nlm.nih.gov/pubmed/34394712
http://dx.doi.org/10.1155/2021/9928986
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author Huang, Chenghu
Lei, Pan
Peng, Caibi
Li, Min
Guo, Yifei
Li, Xuefeng
author_facet Huang, Chenghu
Lei, Pan
Peng, Caibi
Li, Min
Guo, Yifei
Li, Xuefeng
author_sort Huang, Chenghu
collection PubMed
description RESULTS: Prolonged exposure to palmitate increased the expression of ACE and AngII type 1 receptor (ATR1) and decreased the ACE2 expression, which was partly offset by berberine. In ob/ob mice, berberine increased in tolerance to glucose, improved abnormal β-cell and α-cell distributions, upregulated ACE2 expression, and decreased autophagosomes and the expression of LC3 and SQSTM1/p62. Autophagosomes and expression of LC3 and SQSTM1/p62 were increased in ACE2KO mice. CONCLUSIONS: We demonstrated that berberine may improve the pancreatic islet function by regulating local RAS-mediated autophagy under metabolic stress.
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spelling pubmed-83560112021-08-12 Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets Huang, Chenghu Lei, Pan Peng, Caibi Li, Min Guo, Yifei Li, Xuefeng J Renin Angiotensin Aldosterone Syst Research Article RESULTS: Prolonged exposure to palmitate increased the expression of ACE and AngII type 1 receptor (ATR1) and decreased the ACE2 expression, which was partly offset by berberine. In ob/ob mice, berberine increased in tolerance to glucose, improved abnormal β-cell and α-cell distributions, upregulated ACE2 expression, and decreased autophagosomes and the expression of LC3 and SQSTM1/p62. Autophagosomes and expression of LC3 and SQSTM1/p62 were increased in ACE2KO mice. CONCLUSIONS: We demonstrated that berberine may improve the pancreatic islet function by regulating local RAS-mediated autophagy under metabolic stress. Hindawi 2021-08-03 /pmc/articles/PMC8356011/ /pubmed/34394712 http://dx.doi.org/10.1155/2021/9928986 Text en Copyright © 2021 Chenghu Huang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Huang, Chenghu
Lei, Pan
Peng, Caibi
Li, Min
Guo, Yifei
Li, Xuefeng
Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets
title Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets
title_full Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets
title_fullStr Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets
title_full_unstemmed Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets
title_short Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets
title_sort berberine reshapes the balance of the local renin-angiotensin system by modulating autophagy under metabolic stress in pancreatic islets
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356011/
https://www.ncbi.nlm.nih.gov/pubmed/34394712
http://dx.doi.org/10.1155/2021/9928986
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