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The Emerging Roles of CCN3 Protein in Immune-Related Diseases

The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major c...

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Detalles Bibliográficos
Autores principales: Peng, Linan, Wei, Yingying, Shao, Yijia, Li, Yi, Liu, Na, Duan, Lihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356028/
https://www.ncbi.nlm.nih.gov/pubmed/34393649
http://dx.doi.org/10.1155/2021/5576059
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author Peng, Linan
Wei, Yingying
Shao, Yijia
Li, Yi
Liu, Na
Duan, Lihua
author_facet Peng, Linan
Wei, Yingying
Shao, Yijia
Li, Yi
Liu, Na
Duan, Lihua
author_sort Peng, Linan
collection PubMed
description The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major cellular processes such as cell growth, migration, and differentiation. Recently, CCN3 has emerged as a critical regulator in a variety of diseases, including immune-related diseases, including rheumatology arthritis, osteoarthritis, and systemic sclerosis. In this review, we will briefly introduce the structure and function of the CCN3 protein and summarize the roles of CCN3 in immune-related diseases, which is essential to understand the functions of the CCN3 in immune-related diseases.
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spelling pubmed-83560282021-08-12 The Emerging Roles of CCN3 Protein in Immune-Related Diseases Peng, Linan Wei, Yingying Shao, Yijia Li, Yi Liu, Na Duan, Lihua Mediators Inflamm Review Article The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major cellular processes such as cell growth, migration, and differentiation. Recently, CCN3 has emerged as a critical regulator in a variety of diseases, including immune-related diseases, including rheumatology arthritis, osteoarthritis, and systemic sclerosis. In this review, we will briefly introduce the structure and function of the CCN3 protein and summarize the roles of CCN3 in immune-related diseases, which is essential to understand the functions of the CCN3 in immune-related diseases. Hindawi 2021-05-18 /pmc/articles/PMC8356028/ /pubmed/34393649 http://dx.doi.org/10.1155/2021/5576059 Text en Copyright © 2021 Linan Peng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Peng, Linan
Wei, Yingying
Shao, Yijia
Li, Yi
Liu, Na
Duan, Lihua
The Emerging Roles of CCN3 Protein in Immune-Related Diseases
title The Emerging Roles of CCN3 Protein in Immune-Related Diseases
title_full The Emerging Roles of CCN3 Protein in Immune-Related Diseases
title_fullStr The Emerging Roles of CCN3 Protein in Immune-Related Diseases
title_full_unstemmed The Emerging Roles of CCN3 Protein in Immune-Related Diseases
title_short The Emerging Roles of CCN3 Protein in Immune-Related Diseases
title_sort emerging roles of ccn3 protein in immune-related diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356028/
https://www.ncbi.nlm.nih.gov/pubmed/34393649
http://dx.doi.org/10.1155/2021/5576059
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