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The Emerging Roles of CCN3 Protein in Immune-Related Diseases
The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356028/ https://www.ncbi.nlm.nih.gov/pubmed/34393649 http://dx.doi.org/10.1155/2021/5576059 |
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author | Peng, Linan Wei, Yingying Shao, Yijia Li, Yi Liu, Na Duan, Lihua |
author_facet | Peng, Linan Wei, Yingying Shao, Yijia Li, Yi Liu, Na Duan, Lihua |
author_sort | Peng, Linan |
collection | PubMed |
description | The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major cellular processes such as cell growth, migration, and differentiation. Recently, CCN3 has emerged as a critical regulator in a variety of diseases, including immune-related diseases, including rheumatology arthritis, osteoarthritis, and systemic sclerosis. In this review, we will briefly introduce the structure and function of the CCN3 protein and summarize the roles of CCN3 in immune-related diseases, which is essential to understand the functions of the CCN3 in immune-related diseases. |
format | Online Article Text |
id | pubmed-8356028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83560282021-08-12 The Emerging Roles of CCN3 Protein in Immune-Related Diseases Peng, Linan Wei, Yingying Shao, Yijia Li, Yi Liu, Na Duan, Lihua Mediators Inflamm Review Article The CCN proteins are a family of extracellular matrix- (ECM-) associated proteins which currently consist of six secreted proteins (CCN1-6). CCN3 protein, also known as nephroblastoma overexpressed protein (NOV), is a member of the CCN family with multiple biological functions, implicated in major cellular processes such as cell growth, migration, and differentiation. Recently, CCN3 has emerged as a critical regulator in a variety of diseases, including immune-related diseases, including rheumatology arthritis, osteoarthritis, and systemic sclerosis. In this review, we will briefly introduce the structure and function of the CCN3 protein and summarize the roles of CCN3 in immune-related diseases, which is essential to understand the functions of the CCN3 in immune-related diseases. Hindawi 2021-05-18 /pmc/articles/PMC8356028/ /pubmed/34393649 http://dx.doi.org/10.1155/2021/5576059 Text en Copyright © 2021 Linan Peng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Peng, Linan Wei, Yingying Shao, Yijia Li, Yi Liu, Na Duan, Lihua The Emerging Roles of CCN3 Protein in Immune-Related Diseases |
title | The Emerging Roles of CCN3 Protein in Immune-Related Diseases |
title_full | The Emerging Roles of CCN3 Protein in Immune-Related Diseases |
title_fullStr | The Emerging Roles of CCN3 Protein in Immune-Related Diseases |
title_full_unstemmed | The Emerging Roles of CCN3 Protein in Immune-Related Diseases |
title_short | The Emerging Roles of CCN3 Protein in Immune-Related Diseases |
title_sort | emerging roles of ccn3 protein in immune-related diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356028/ https://www.ncbi.nlm.nih.gov/pubmed/34393649 http://dx.doi.org/10.1155/2021/5576059 |
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