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Jojoba oil-based microemulsion for transdermal drug delivery
BACKGROUND AND PURPOSE: Microemulsions are gaining an increased interest in transdermal drug delivery. Microemulsions are stable, easy to prepare, and provide high solubilizing capacity for various drugs. The aim of this work was to prepare microemulsions from jojoba oil for transdermal delivery of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356718/ https://www.ncbi.nlm.nih.gov/pubmed/34447442 http://dx.doi.org/10.4103/1735-5362.319572 |
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author | Assaf, Shereen Mashhour Maaroof, Khalid Taieb Altaani, Bashar Mohammad Ghareeb, Mowafaq Mohammed Abu Alhayyal, Amane Awad |
author_facet | Assaf, Shereen Mashhour Maaroof, Khalid Taieb Altaani, Bashar Mohammad Ghareeb, Mowafaq Mohammed Abu Alhayyal, Amane Awad |
author_sort | Assaf, Shereen Mashhour |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Microemulsions are gaining an increased interest in transdermal drug delivery. Microemulsions are stable, easy to prepare, and provide high solubilizing capacity for various drugs. The aim of this work was to prepare microemulsions from jojoba oil for transdermal delivery of ketorolac and lidocaine HCl with improved permeation. EXPERIMENTAL APPROACH: Microemulsions based on jojoba oil as the oil phase were formulated for transdermal delivery of lidocaine HCl and ketorolac. Brij 97 was selected as surfactant and hexanol as cosurfactant. Pseudoternary phase diagrams were constructed. Selected microemulsion formulations were characterized for their physical properties and in vitro drug permeation. FINDINGS/RESULTS: Water-in-oil microemulsions were obtained with droplet sizes not more than 220 nm. The viscosity of the microemulsions was linked to the viscosity of the surfactant used. Improved drug permeation rates were observed for both model drugs. The significant increase in permeation rate in presence of hexanol was due to its impact on skin integrity as indicated by the histopathological study. Drug permeation enhancements were caused by the surfactant, the cosurfactant used, jojoba oil itself, and the microemulsion formulation. Higher surfactant content showed lower lag times and better flux. CONCLUSION AND IMPLICATIONS: Jojoba oil microemulsions are considered promising vehicles for transdermal delivery of ketorolac and lidocaine HCl with improved drug permeation. Jojoba oil-based microemulsion would present a safe and effective means for delivering drugs through the skin. |
format | Online Article Text |
id | pubmed-8356718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-83567182021-08-25 Jojoba oil-based microemulsion for transdermal drug delivery Assaf, Shereen Mashhour Maaroof, Khalid Taieb Altaani, Bashar Mohammad Ghareeb, Mowafaq Mohammed Abu Alhayyal, Amane Awad Res Pharm Sci Original Article BACKGROUND AND PURPOSE: Microemulsions are gaining an increased interest in transdermal drug delivery. Microemulsions are stable, easy to prepare, and provide high solubilizing capacity for various drugs. The aim of this work was to prepare microemulsions from jojoba oil for transdermal delivery of ketorolac and lidocaine HCl with improved permeation. EXPERIMENTAL APPROACH: Microemulsions based on jojoba oil as the oil phase were formulated for transdermal delivery of lidocaine HCl and ketorolac. Brij 97 was selected as surfactant and hexanol as cosurfactant. Pseudoternary phase diagrams were constructed. Selected microemulsion formulations were characterized for their physical properties and in vitro drug permeation. FINDINGS/RESULTS: Water-in-oil microemulsions were obtained with droplet sizes not more than 220 nm. The viscosity of the microemulsions was linked to the viscosity of the surfactant used. Improved drug permeation rates were observed for both model drugs. The significant increase in permeation rate in presence of hexanol was due to its impact on skin integrity as indicated by the histopathological study. Drug permeation enhancements were caused by the surfactant, the cosurfactant used, jojoba oil itself, and the microemulsion formulation. Higher surfactant content showed lower lag times and better flux. CONCLUSION AND IMPLICATIONS: Jojoba oil microemulsions are considered promising vehicles for transdermal delivery of ketorolac and lidocaine HCl with improved drug permeation. Jojoba oil-based microemulsion would present a safe and effective means for delivering drugs through the skin. Wolters Kluwer - Medknow 2021-06-30 /pmc/articles/PMC8356718/ /pubmed/34447442 http://dx.doi.org/10.4103/1735-5362.319572 Text en Copyright: © 2021 Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Assaf, Shereen Mashhour Maaroof, Khalid Taieb Altaani, Bashar Mohammad Ghareeb, Mowafaq Mohammed Abu Alhayyal, Amane Awad Jojoba oil-based microemulsion for transdermal drug delivery |
title | Jojoba oil-based microemulsion for transdermal drug delivery |
title_full | Jojoba oil-based microemulsion for transdermal drug delivery |
title_fullStr | Jojoba oil-based microemulsion for transdermal drug delivery |
title_full_unstemmed | Jojoba oil-based microemulsion for transdermal drug delivery |
title_short | Jojoba oil-based microemulsion for transdermal drug delivery |
title_sort | jojoba oil-based microemulsion for transdermal drug delivery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356718/ https://www.ncbi.nlm.nih.gov/pubmed/34447442 http://dx.doi.org/10.4103/1735-5362.319572 |
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