Modeling of DNA binding to the condensin hinge domain using molecular dynamics simulations guided by atomic force microscopy

The condensin protein complex compacts chromatin during mitosis using its DNA-loop extrusion activity. Previous studies proposed scrunching and loop-capture models as molecular mechanisms for the loop extrusion process, both of which assume the binding of double-strand (ds) DNA to the hinge domain f...

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Detalles Bibliográficos
Autores principales: Koide, Hiroki, Kodera, Noriyuki, Bisht, Shveta, Takada, Shoji, Terakawa, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357123/
https://www.ncbi.nlm.nih.gov/pubmed/34329301
http://dx.doi.org/10.1371/journal.pcbi.1009265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357123/
https://www.ncbi.nlm.nih.gov/pubmed/34329301
http://dx.doi.org/10.1371/journal.pcbi.1009265

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