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Modeling of DNA binding to the condensin hinge domain using molecular dynamics simulations guided by atomic force microscopy
The condensin protein complex compacts chromatin during mitosis using its DNA-loop extrusion activity. Previous studies proposed scrunching and loop-capture models as molecular mechanisms for the loop extrusion process, both of which assume the binding of double-strand (ds) DNA to the hinge domain f...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357123/ https://www.ncbi.nlm.nih.gov/pubmed/34329301 http://dx.doi.org/10.1371/journal.pcbi.1009265 |