Cargando…

Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study

Menopausal hormone therapy (MHT) is effective for menopausal symptoms, however, its use is also associated with risks of serious health conditions including breast, ovarian and endometrial cancer, stroke and venous thromboembolism. MHT-related health risks increase with longer durations of use. In A...

Descripción completa

Detalles Bibliográficos
Autores principales: Velentzis, Louiza S., Egger, Sam, Banks, Emily, Canfell, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357145/
https://www.ncbi.nlm.nih.gov/pubmed/34379634
http://dx.doi.org/10.1371/journal.pone.0253725
_version_ 1783737083122155520
author Velentzis, Louiza S.
Egger, Sam
Banks, Emily
Canfell, Karen
author_facet Velentzis, Louiza S.
Egger, Sam
Banks, Emily
Canfell, Karen
author_sort Velentzis, Louiza S.
collection PubMed
description Menopausal hormone therapy (MHT) is effective for menopausal symptoms, however, its use is also associated with risks of serious health conditions including breast, ovarian and endometrial cancer, stroke and venous thromboembolism. MHT-related health risks increase with longer durations of use. In Australia, while overall MHT use fell when risk-related findings were published in 2002, a significant number of women continue using MHT long-term. We aimed to examine socio-demographic, health-related and lifestyle characteristics in relation to post-2002 MHT use, and to compare use for <5 and ≥5 years. Data from 1,561 participants from an Australian, national, cross-sectional survey of women aged 50–69 in 2013 were analysed. Odds ratios (ORs) were calculated using logistic regression for characteristics related to overall MHT use post-2002 and multinomial logistic regression for associations between MHT duration of use [never/<5 years/≥5 years] and personal characteristics, adjusting for sociodemographic, reproductive, health and lifestyle factors. Post-2002 MHT use was associated with increasing age (p-trend<0.001), hysterectomy versus no hysterectomy (OR:2.55, 95%CI = 1.85–3.51), bilateral oophorectomy vs no oophorectomy (OR:1.66, 95%CI = 1.09–2.53), and ever- versus never-use of therapies other than MHT for menopausal symptoms (OR:1.93, 95%CI = 1.48–2.57). Women with prior breast cancer (OR:0.35, 95%CI = 0.17–0.74) and with more children (p-trend = 0.034) were less likely than other women to use MHT. Prior hysterectomy was more strongly associated with MHT use for ≥5 years than for <5 years (p = 0.004). Ever-use of non-MHT menopausal therapies was associated with MHT use for <5 years but not with longer-term use (p = 0.004). This study reinforces the need for MHT users and their clinicians to re-evaluate continued MHT use on an ongoing basis.
format Online
Article
Text
id pubmed-8357145
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-83571452021-08-12 Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study Velentzis, Louiza S. Egger, Sam Banks, Emily Canfell, Karen PLoS One Research Article Menopausal hormone therapy (MHT) is effective for menopausal symptoms, however, its use is also associated with risks of serious health conditions including breast, ovarian and endometrial cancer, stroke and venous thromboembolism. MHT-related health risks increase with longer durations of use. In Australia, while overall MHT use fell when risk-related findings were published in 2002, a significant number of women continue using MHT long-term. We aimed to examine socio-demographic, health-related and lifestyle characteristics in relation to post-2002 MHT use, and to compare use for <5 and ≥5 years. Data from 1,561 participants from an Australian, national, cross-sectional survey of women aged 50–69 in 2013 were analysed. Odds ratios (ORs) were calculated using logistic regression for characteristics related to overall MHT use post-2002 and multinomial logistic regression for associations between MHT duration of use [never/<5 years/≥5 years] and personal characteristics, adjusting for sociodemographic, reproductive, health and lifestyle factors. Post-2002 MHT use was associated with increasing age (p-trend<0.001), hysterectomy versus no hysterectomy (OR:2.55, 95%CI = 1.85–3.51), bilateral oophorectomy vs no oophorectomy (OR:1.66, 95%CI = 1.09–2.53), and ever- versus never-use of therapies other than MHT for menopausal symptoms (OR:1.93, 95%CI = 1.48–2.57). Women with prior breast cancer (OR:0.35, 95%CI = 0.17–0.74) and with more children (p-trend = 0.034) were less likely than other women to use MHT. Prior hysterectomy was more strongly associated with MHT use for ≥5 years than for <5 years (p = 0.004). Ever-use of non-MHT menopausal therapies was associated with MHT use for <5 years but not with longer-term use (p = 0.004). This study reinforces the need for MHT users and their clinicians to re-evaluate continued MHT use on an ongoing basis. Public Library of Science 2021-08-11 /pmc/articles/PMC8357145/ /pubmed/34379634 http://dx.doi.org/10.1371/journal.pone.0253725 Text en © 2021 Velentzis et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Velentzis, Louiza S.
Egger, Sam
Banks, Emily
Canfell, Karen
Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study
title Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study
title_full Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study
title_fullStr Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study
title_full_unstemmed Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study
title_short Menopausal hormone therapy: Characterising users in an Australian national cross-sectional study
title_sort menopausal hormone therapy: characterising users in an australian national cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357145/
https://www.ncbi.nlm.nih.gov/pubmed/34379634
http://dx.doi.org/10.1371/journal.pone.0253725
work_keys_str_mv AT velentzislouizas menopausalhormonetherapycharacterisingusersinanaustraliannationalcrosssectionalstudy
AT eggersam menopausalhormonetherapycharacterisingusersinanaustraliannationalcrosssectionalstudy
AT banksemily menopausalhormonetherapycharacterisingusersinanaustraliannationalcrosssectionalstudy
AT canfellkaren menopausalhormonetherapycharacterisingusersinanaustraliannationalcrosssectionalstudy