Cell therapy strategies for COVID-19: Current approaches and potential applications

Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most patients having a mild course, severe presentations have limited treatment options. COVID-19 manifestations extend beyond the lungs and may affect the cardiovascular, nervous, and other organ systems. Current tre...

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Detalles Bibliográficos
Autores principales: Zaki, Mark M., Lesha, Emal, Said, Khaled, Kiaee, Kiavash, Robinson-McCarthy, Lindsey, George, Haydy, Hanna, Angy, Appleton, Evan, Liu, Songlei, Ng, Alex H. M., Khoshakhlagh, Parastoo, Church, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357240/
https://www.ncbi.nlm.nih.gov/pubmed/34380619
http://dx.doi.org/10.1126/sciadv.abg5995
Descripción
Sumario:Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most patients having a mild course, severe presentations have limited treatment options. COVID-19 manifestations extend beyond the lungs and may affect the cardiovascular, nervous, and other organ systems. Current treatments are nonspecific and do not address potential long-term consequences such as pulmonary fibrosis, demyelination, and ischemic organ damage. Cell therapies offer great potential in treating severe COVID-19 presentations due to their customizability and regenerative function. This review summarizes COVID-19 pathogenesis, respective areas where cell therapies have potential, and the ongoing 89 cell therapy trials in COVID-19 as of 1 January 2021.

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