Cell therapy strategies for COVID-19: Current approaches and potential applications

Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most patients having a mild course, severe presentations have limited treatment options. COVID-19 manifestations extend beyond the lungs and may affect the cardiovascular, nervous, and other organ systems. Current tre...

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Autores principales: Zaki, Mark M., Lesha, Emal, Said, Khaled, Kiaee, Kiavash, Robinson-McCarthy, Lindsey, George, Haydy, Hanna, Angy, Appleton, Evan, Liu, Songlei, Ng, Alex H. M., Khoshakhlagh, Parastoo, Church, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357240/
https://www.ncbi.nlm.nih.gov/pubmed/34380619
http://dx.doi.org/10.1126/sciadv.abg5995
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author Zaki, Mark M.
Lesha, Emal
Said, Khaled
Kiaee, Kiavash
Robinson-McCarthy, Lindsey
George, Haydy
Hanna, Angy
Appleton, Evan
Liu, Songlei
Ng, Alex H. M.
Khoshakhlagh, Parastoo
Church, George M.
author_facet Zaki, Mark M.
Lesha, Emal
Said, Khaled
Kiaee, Kiavash
Robinson-McCarthy, Lindsey
George, Haydy
Hanna, Angy
Appleton, Evan
Liu, Songlei
Ng, Alex H. M.
Khoshakhlagh, Parastoo
Church, George M.
author_sort Zaki, Mark M.
collection PubMed
description Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most patients having a mild course, severe presentations have limited treatment options. COVID-19 manifestations extend beyond the lungs and may affect the cardiovascular, nervous, and other organ systems. Current treatments are nonspecific and do not address potential long-term consequences such as pulmonary fibrosis, demyelination, and ischemic organ damage. Cell therapies offer great potential in treating severe COVID-19 presentations due to their customizability and regenerative function. This review summarizes COVID-19 pathogenesis, respective areas where cell therapies have potential, and the ongoing 89 cell therapy trials in COVID-19 as of 1 January 2021.
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spelling pubmed-83572402021-08-20 Cell therapy strategies for COVID-19: Current approaches and potential applications Zaki, Mark M. Lesha, Emal Said, Khaled Kiaee, Kiavash Robinson-McCarthy, Lindsey George, Haydy Hanna, Angy Appleton, Evan Liu, Songlei Ng, Alex H. M. Khoshakhlagh, Parastoo Church, George M. Sci Adv Reviews Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most patients having a mild course, severe presentations have limited treatment options. COVID-19 manifestations extend beyond the lungs and may affect the cardiovascular, nervous, and other organ systems. Current treatments are nonspecific and do not address potential long-term consequences such as pulmonary fibrosis, demyelination, and ischemic organ damage. Cell therapies offer great potential in treating severe COVID-19 presentations due to their customizability and regenerative function. This review summarizes COVID-19 pathogenesis, respective areas where cell therapies have potential, and the ongoing 89 cell therapy trials in COVID-19 as of 1 January 2021. American Association for the Advancement of Science 2021-08-11 /pmc/articles/PMC8357240/ /pubmed/34380619 http://dx.doi.org/10.1126/sciadv.abg5995 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Zaki, Mark M.
Lesha, Emal
Said, Khaled
Kiaee, Kiavash
Robinson-McCarthy, Lindsey
George, Haydy
Hanna, Angy
Appleton, Evan
Liu, Songlei
Ng, Alex H. M.
Khoshakhlagh, Parastoo
Church, George M.
Cell therapy strategies for COVID-19: Current approaches and potential applications
title Cell therapy strategies for COVID-19: Current approaches and potential applications
title_full Cell therapy strategies for COVID-19: Current approaches and potential applications
title_fullStr Cell therapy strategies for COVID-19: Current approaches and potential applications
title_full_unstemmed Cell therapy strategies for COVID-19: Current approaches and potential applications
title_short Cell therapy strategies for COVID-19: Current approaches and potential applications
title_sort cell therapy strategies for covid-19: current approaches and potential applications
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357240/
https://www.ncbi.nlm.nih.gov/pubmed/34380619
http://dx.doi.org/10.1126/sciadv.abg5995
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