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Single-molecule measurements reveal that PARP1 condenses DNA by loop stabilization

Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear enzyme that plays important roles in DNA repair, chromatin organization and transcription regulation. Although binding and activation of PARP1 by DNA damage sites has been extensively studied, little is known about how PARP1 binds to long...

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Detalles Bibliográficos
Autores principales:	Bell, Nicholas A. W., Haynes, Philip J., Brunner, Katharina, de Oliveira, Taiana Maia, Flocco, Maria M., Hoogenboom, Bart W., Molloy, Justin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357241/ https://www.ncbi.nlm.nih.gov/pubmed/34380612 http://dx.doi.org/10.1126/sciadv.abf3641

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