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Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis

INTRODUCTION: Transient receptor potential vanilloid 4 (TRPV4) modulates osteoarthritic (OA) pain in animal models. However, the pathophysiological function of TRPV4 in regulating OA pain remains poorly understood. METHODS: We developed TRPV4-knockout (TRPV4-KO) rats and assessed the effects of Trpv...

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Detalles Bibliográficos
Autores principales: Soga, Masahiko, Izumi, Takaya, Nanchi, Isamu, Horita, Narumi, Yamamoto, Miyuki, Kawasaki, Shiori, Ogawa, Koichi, Fujita, Masahide, Morioka, Yasuhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357256/
https://www.ncbi.nlm.nih.gov/pubmed/34396019
http://dx.doi.org/10.1097/PR9.0000000000000951

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