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Fully automated fiber-based optical spectroscopy system for use in a clinical setting
While there are a plethora of in vivo fiber-optic spectroscopic techniques that have demonstrated the ability to detect a number of diseases in research trials with highly trained personnel familiar with the operation of experimental optical technologies, very few techniques show the same level of s...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Photo-Optical Instrumentation Engineers
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357326/ https://www.ncbi.nlm.nih.gov/pubmed/29981224 http://dx.doi.org/10.1117/1.JBO.23.7.075003 |
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author | Eshein, Adam Radosevich, Andrew J. Gould, Bradley Wu, Wenli Konda, Vani Yang, Leslie W. Koons, Ann Feder, Seth Valuckaite, Vesta Roy, Hemant K. Backman, Vadim Nguyen, The-Quyen |
author_facet | Eshein, Adam Radosevich, Andrew J. Gould, Bradley Wu, Wenli Konda, Vani Yang, Leslie W. Koons, Ann Feder, Seth Valuckaite, Vesta Roy, Hemant K. Backman, Vadim Nguyen, The-Quyen |
author_sort | Eshein, Adam |
collection | PubMed |
description | While there are a plethora of in vivo fiber-optic spectroscopic techniques that have demonstrated the ability to detect a number of diseases in research trials with highly trained personnel familiar with the operation of experimental optical technologies, very few techniques show the same level of success in large multicenter trials. To meet the stringent requirements for a viable optical spectroscopy system to be used in a clinical setting, we developed components including an automated calibration tool, optical contact sensor for signal acquisition, and a methodology for real-time in vivo probe calibration correction. The end result is a state-of-the-art medical device that can be realistically used by a physician with spectroscopic fiber-optic probes. We show how the features of this system allow it to have excellent stability measuring two scattering phantoms in a clinical setting by clinical staff with [Formula: see text] standard deviation over 25 unique measurements on different days. In addition, we show the systems’ ability to overcome many technical obstacles that spectroscopy applications often face such as speckle noise and user variability. While this system has been designed and optimized for our specific application, the system and design concepts are applicable to most in vivo fiber-optic-based spectroscopic techniques. |
format | Online Article Text |
id | pubmed-8357326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Society of Photo-Optical Instrumentation Engineers |
record_format | MEDLINE/PubMed |
spelling | pubmed-83573262021-08-12 Fully automated fiber-based optical spectroscopy system for use in a clinical setting Eshein, Adam Radosevich, Andrew J. Gould, Bradley Wu, Wenli Konda, Vani Yang, Leslie W. Koons, Ann Feder, Seth Valuckaite, Vesta Roy, Hemant K. Backman, Vadim Nguyen, The-Quyen J Biomed Opt General While there are a plethora of in vivo fiber-optic spectroscopic techniques that have demonstrated the ability to detect a number of diseases in research trials with highly trained personnel familiar with the operation of experimental optical technologies, very few techniques show the same level of success in large multicenter trials. To meet the stringent requirements for a viable optical spectroscopy system to be used in a clinical setting, we developed components including an automated calibration tool, optical contact sensor for signal acquisition, and a methodology for real-time in vivo probe calibration correction. The end result is a state-of-the-art medical device that can be realistically used by a physician with spectroscopic fiber-optic probes. We show how the features of this system allow it to have excellent stability measuring two scattering phantoms in a clinical setting by clinical staff with [Formula: see text] standard deviation over 25 unique measurements on different days. In addition, we show the systems’ ability to overcome many technical obstacles that spectroscopy applications often face such as speckle noise and user variability. While this system has been designed and optimized for our specific application, the system and design concepts are applicable to most in vivo fiber-optic-based spectroscopic techniques. Society of Photo-Optical Instrumentation Engineers 2018-07-06 2018-07 /pmc/articles/PMC8357326/ /pubmed/29981224 http://dx.doi.org/10.1117/1.JBO.23.7.075003 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. |
spellingShingle | General Eshein, Adam Radosevich, Andrew J. Gould, Bradley Wu, Wenli Konda, Vani Yang, Leslie W. Koons, Ann Feder, Seth Valuckaite, Vesta Roy, Hemant K. Backman, Vadim Nguyen, The-Quyen Fully automated fiber-based optical spectroscopy system for use in a clinical setting |
title | Fully automated fiber-based optical spectroscopy system for use in a clinical setting |
title_full | Fully automated fiber-based optical spectroscopy system for use in a clinical setting |
title_fullStr | Fully automated fiber-based optical spectroscopy system for use in a clinical setting |
title_full_unstemmed | Fully automated fiber-based optical spectroscopy system for use in a clinical setting |
title_short | Fully automated fiber-based optical spectroscopy system for use in a clinical setting |
title_sort | fully automated fiber-based optical spectroscopy system for use in a clinical setting |
topic | General |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357326/ https://www.ncbi.nlm.nih.gov/pubmed/29981224 http://dx.doi.org/10.1117/1.JBO.23.7.075003 |
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