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Fetal and Neonatal Modified Myocardial Performance Indices in Preeclamptic versus Normotensive Pregnancies: A Prospective Cohort Study

OBJECTIVE: To compare fetal and neonatal cardiac functions in terms of global, systolic, and diastolic function between the preeclampsia and normotensive blood pressure of pregnancies. METHODS: A prospective cohort study was conducted at a university hospital in Northeast Thailand. Twenty-nine pregn...

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Autores principales: Promket, Anutsara, Duangkum, Chatuporn, Wongswadiwat, Yuttapong, Saksiriwuttho, Piyamas, Chaiyarach, Sukanya, Kongwattanakul, Kiattisak, Komwilaisak, Ratana, Lumbiganon, Pisake, Sirikan, Prapassara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357402/
https://www.ncbi.nlm.nih.gov/pubmed/34393519
http://dx.doi.org/10.2147/IJWH.S316351
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author Promket, Anutsara
Duangkum, Chatuporn
Wongswadiwat, Yuttapong
Saksiriwuttho, Piyamas
Chaiyarach, Sukanya
Kongwattanakul, Kiattisak
Komwilaisak, Ratana
Lumbiganon, Pisake
Sirikan, Prapassara
author_facet Promket, Anutsara
Duangkum, Chatuporn
Wongswadiwat, Yuttapong
Saksiriwuttho, Piyamas
Chaiyarach, Sukanya
Kongwattanakul, Kiattisak
Komwilaisak, Ratana
Lumbiganon, Pisake
Sirikan, Prapassara
author_sort Promket, Anutsara
collection PubMed
description OBJECTIVE: To compare fetal and neonatal cardiac functions in terms of global, systolic, and diastolic function between the preeclampsia and normotensive blood pressure of pregnancies. METHODS: A prospective cohort study was conducted at a university hospital in Northeast Thailand. Twenty-nine pregnancies diagnosed as preeclampsia with or without severe features were compared with 29 normotensive pregnancies. Global cardiac, systolic, and diastolic function were assessed at prenatal and postnatal periods, by a professionally trained obstetrician and pediatric cardiologist, respectively. RESULTS: The fetal left modified myocardium performance index (Mod-MPI) in preeclampsia and normotensive blood pressure were 0.60±0.08 and 0.59±0.08 (p-value=0.341), respectively, while fetal right Mod-MPI were 0.57±0.16 and 0.54±0.21 (p-value=0.861), respectively. There were no statistically significant differences in terms of fetal isovolumic contraction time (ICT), isovolumic relaxation time (IRT), ejection time (ET), aortic peak systolic velocity (Ao PSV), pulmonary artery peak systolic velocity (PA PSV), mitral valve (MV) E:A ratio, or tricuspid valve (TV) E:A ratios between the two groups. Neonatal mitral valve E peak systolic velocity (MV-E PV) in preeclamptic and normotensive blood pressure groups were significantly different at 51.1±8.02 cm/s and 43.56±5.21cm/s (p-value=0.036), respectively, whereas neonatal left Mod-MPI, mitral valve A peak systolic velocity (MV-A PV), MV E:A ratio, and Ao PSV were not significantly different (p-value=0.436, 0.119, 0.379, and 0.709), respectively. CONCLUSION: Neonatal MV-E PV of the preeclampsia group was significantly higher than the normotensive blood pressure group, while there were no statistically significant differences in terms of global cardiac and diastolic functions during the fetal period between two groups.
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spelling pubmed-83574022021-08-12 Fetal and Neonatal Modified Myocardial Performance Indices in Preeclamptic versus Normotensive Pregnancies: A Prospective Cohort Study Promket, Anutsara Duangkum, Chatuporn Wongswadiwat, Yuttapong Saksiriwuttho, Piyamas Chaiyarach, Sukanya Kongwattanakul, Kiattisak Komwilaisak, Ratana Lumbiganon, Pisake Sirikan, Prapassara Int J Womens Health Original Research OBJECTIVE: To compare fetal and neonatal cardiac functions in terms of global, systolic, and diastolic function between the preeclampsia and normotensive blood pressure of pregnancies. METHODS: A prospective cohort study was conducted at a university hospital in Northeast Thailand. Twenty-nine pregnancies diagnosed as preeclampsia with or without severe features were compared with 29 normotensive pregnancies. Global cardiac, systolic, and diastolic function were assessed at prenatal and postnatal periods, by a professionally trained obstetrician and pediatric cardiologist, respectively. RESULTS: The fetal left modified myocardium performance index (Mod-MPI) in preeclampsia and normotensive blood pressure were 0.60±0.08 and 0.59±0.08 (p-value=0.341), respectively, while fetal right Mod-MPI were 0.57±0.16 and 0.54±0.21 (p-value=0.861), respectively. There were no statistically significant differences in terms of fetal isovolumic contraction time (ICT), isovolumic relaxation time (IRT), ejection time (ET), aortic peak systolic velocity (Ao PSV), pulmonary artery peak systolic velocity (PA PSV), mitral valve (MV) E:A ratio, or tricuspid valve (TV) E:A ratios between the two groups. Neonatal mitral valve E peak systolic velocity (MV-E PV) in preeclamptic and normotensive blood pressure groups were significantly different at 51.1±8.02 cm/s and 43.56±5.21cm/s (p-value=0.036), respectively, whereas neonatal left Mod-MPI, mitral valve A peak systolic velocity (MV-A PV), MV E:A ratio, and Ao PSV were not significantly different (p-value=0.436, 0.119, 0.379, and 0.709), respectively. CONCLUSION: Neonatal MV-E PV of the preeclampsia group was significantly higher than the normotensive blood pressure group, while there were no statistically significant differences in terms of global cardiac and diastolic functions during the fetal period between two groups. Dove 2021-08-07 /pmc/articles/PMC8357402/ /pubmed/34393519 http://dx.doi.org/10.2147/IJWH.S316351 Text en © 2021 Promket et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Promket, Anutsara
Duangkum, Chatuporn
Wongswadiwat, Yuttapong
Saksiriwuttho, Piyamas
Chaiyarach, Sukanya
Kongwattanakul, Kiattisak
Komwilaisak, Ratana
Lumbiganon, Pisake
Sirikan, Prapassara
Fetal and Neonatal Modified Myocardial Performance Indices in Preeclamptic versus Normotensive Pregnancies: A Prospective Cohort Study
title Fetal and Neonatal Modified Myocardial Performance Indices in Preeclamptic versus Normotensive Pregnancies: A Prospective Cohort Study
title_full Fetal and Neonatal Modified Myocardial Performance Indices in Preeclamptic versus Normotensive Pregnancies: A Prospective Cohort Study
title_fullStr Fetal and Neonatal Modified Myocardial Performance Indices in Preeclamptic versus Normotensive Pregnancies: A Prospective Cohort Study
title_full_unstemmed Fetal and Neonatal Modified Myocardial Performance Indices in Preeclamptic versus Normotensive Pregnancies: A Prospective Cohort Study
title_short Fetal and Neonatal Modified Myocardial Performance Indices in Preeclamptic versus Normotensive Pregnancies: A Prospective Cohort Study
title_sort fetal and neonatal modified myocardial performance indices in preeclamptic versus normotensive pregnancies: a prospective cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357402/
https://www.ncbi.nlm.nih.gov/pubmed/34393519
http://dx.doi.org/10.2147/IJWH.S316351
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