Cargando…

Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke

Skilled movements rely on a coordinated cortical and subcortical network, but how this network supports motor recovery after stroke is unknown. Previous studies focused on the perilesional cortex (PLC), but precisely how connected subcortical areas reorganize and coordinate with PLC is unclear. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Ling, Kondapavulur, Sravani, Lemke, Stefan M., Won, Seok Joon, Ganguly, Karunesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357409/
https://www.ncbi.nlm.nih.gov/pubmed/34260929
http://dx.doi.org/10.1016/j.celrep.2021.109370
_version_ 1783737124621647872
author Guo, Ling
Kondapavulur, Sravani
Lemke, Stefan M.
Won, Seok Joon
Ganguly, Karunesh
author_facet Guo, Ling
Kondapavulur, Sravani
Lemke, Stefan M.
Won, Seok Joon
Ganguly, Karunesh
author_sort Guo, Ling
collection PubMed
description Skilled movements rely on a coordinated cortical and subcortical network, but how this network supports motor recovery after stroke is unknown. Previous studies focused on the perilesional cortex (PLC), but precisely how connected subcortical areas reorganize and coordinate with PLC is unclear. The dorsolateral striatum (DLS) is of interest because it receives monosynaptic inputs from motor cortex and is important for learning and generation of fast reliable actions. Using a rat focal stroke model, we perform chronic electrophysiological recordings in motor PLC and DLS during long-term recovery of a dexterous skill. We find that recovery is associated with the simultaneous emergence of reliable movement-related single-trial ensemble spiking in both structures along with increased cross-area alignment of spiking. Our study highlights the importance of consistent neural activity patterns across brain structures during recovery and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function post-stroke.
format Online
Article
Text
id pubmed-8357409
institution National Center for Biotechnology Information
language English
publishDate 2021
record_format MEDLINE/PubMed
spelling pubmed-83574092021-08-11 Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke Guo, Ling Kondapavulur, Sravani Lemke, Stefan M. Won, Seok Joon Ganguly, Karunesh Cell Rep Article Skilled movements rely on a coordinated cortical and subcortical network, but how this network supports motor recovery after stroke is unknown. Previous studies focused on the perilesional cortex (PLC), but precisely how connected subcortical areas reorganize and coordinate with PLC is unclear. The dorsolateral striatum (DLS) is of interest because it receives monosynaptic inputs from motor cortex and is important for learning and generation of fast reliable actions. Using a rat focal stroke model, we perform chronic electrophysiological recordings in motor PLC and DLS during long-term recovery of a dexterous skill. We find that recovery is associated with the simultaneous emergence of reliable movement-related single-trial ensemble spiking in both structures along with increased cross-area alignment of spiking. Our study highlights the importance of consistent neural activity patterns across brain structures during recovery and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function post-stroke. 2021-07-13 /pmc/articles/PMC8357409/ /pubmed/34260929 http://dx.doi.org/10.1016/j.celrep.2021.109370 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/Cell Reports 36, 109370, July 13, 2021 1 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Guo, Ling
Kondapavulur, Sravani
Lemke, Stefan M.
Won, Seok Joon
Ganguly, Karunesh
Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke
title Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke
title_full Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke
title_fullStr Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke
title_full_unstemmed Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke
title_short Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke
title_sort coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357409/
https://www.ncbi.nlm.nih.gov/pubmed/34260929
http://dx.doi.org/10.1016/j.celrep.2021.109370
work_keys_str_mv AT guoling coordinatedincreaseofreliablecorticalandstriatalensembleactivationsduringrecoveryafterstroke
AT kondapavulursravani coordinatedincreaseofreliablecorticalandstriatalensembleactivationsduringrecoveryafterstroke
AT lemkestefanm coordinatedincreaseofreliablecorticalandstriatalensembleactivationsduringrecoveryafterstroke
AT wonseokjoon coordinatedincreaseofreliablecorticalandstriatalensembleactivationsduringrecoveryafterstroke
AT gangulykarunesh coordinatedincreaseofreliablecorticalandstriatalensembleactivationsduringrecoveryafterstroke