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Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke
Skilled movements rely on a coordinated cortical and subcortical network, but how this network supports motor recovery after stroke is unknown. Previous studies focused on the perilesional cortex (PLC), but precisely how connected subcortical areas reorganize and coordinate with PLC is unclear. The...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357409/ https://www.ncbi.nlm.nih.gov/pubmed/34260929 http://dx.doi.org/10.1016/j.celrep.2021.109370 |
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author | Guo, Ling Kondapavulur, Sravani Lemke, Stefan M. Won, Seok Joon Ganguly, Karunesh |
author_facet | Guo, Ling Kondapavulur, Sravani Lemke, Stefan M. Won, Seok Joon Ganguly, Karunesh |
author_sort | Guo, Ling |
collection | PubMed |
description | Skilled movements rely on a coordinated cortical and subcortical network, but how this network supports motor recovery after stroke is unknown. Previous studies focused on the perilesional cortex (PLC), but precisely how connected subcortical areas reorganize and coordinate with PLC is unclear. The dorsolateral striatum (DLS) is of interest because it receives monosynaptic inputs from motor cortex and is important for learning and generation of fast reliable actions. Using a rat focal stroke model, we perform chronic electrophysiological recordings in motor PLC and DLS during long-term recovery of a dexterous skill. We find that recovery is associated with the simultaneous emergence of reliable movement-related single-trial ensemble spiking in both structures along with increased cross-area alignment of spiking. Our study highlights the importance of consistent neural activity patterns across brain structures during recovery and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function post-stroke. |
format | Online Article Text |
id | pubmed-8357409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-83574092021-08-11 Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke Guo, Ling Kondapavulur, Sravani Lemke, Stefan M. Won, Seok Joon Ganguly, Karunesh Cell Rep Article Skilled movements rely on a coordinated cortical and subcortical network, but how this network supports motor recovery after stroke is unknown. Previous studies focused on the perilesional cortex (PLC), but precisely how connected subcortical areas reorganize and coordinate with PLC is unclear. The dorsolateral striatum (DLS) is of interest because it receives monosynaptic inputs from motor cortex and is important for learning and generation of fast reliable actions. Using a rat focal stroke model, we perform chronic electrophysiological recordings in motor PLC and DLS during long-term recovery of a dexterous skill. We find that recovery is associated with the simultaneous emergence of reliable movement-related single-trial ensemble spiking in both structures along with increased cross-area alignment of spiking. Our study highlights the importance of consistent neural activity patterns across brain structures during recovery and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function post-stroke. 2021-07-13 /pmc/articles/PMC8357409/ /pubmed/34260929 http://dx.doi.org/10.1016/j.celrep.2021.109370 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/Cell Reports 36, 109370, July 13, 2021 1 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Guo, Ling Kondapavulur, Sravani Lemke, Stefan M. Won, Seok Joon Ganguly, Karunesh Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke |
title | Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke |
title_full | Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke |
title_fullStr | Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke |
title_full_unstemmed | Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke |
title_short | Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke |
title_sort | coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357409/ https://www.ncbi.nlm.nih.gov/pubmed/34260929 http://dx.doi.org/10.1016/j.celrep.2021.109370 |
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