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Impaired neural replay of inferred relationships in schizophrenia

An ability to build structured mental maps of the world underpins our capacity to imagine relationships between objects that extend beyond experience. In rodents, such representations are supported by sequential place cell reactivations during rest, known as replay. Schizophrenia is proposed to refl...

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Autores principales: Nour, Matthew M., Liu, Yunzhe, Arumuham, Atheeshaan, Kurth-Nelson, Zeb, Dolan, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357425/
https://www.ncbi.nlm.nih.gov/pubmed/34197734
http://dx.doi.org/10.1016/j.cell.2021.06.012
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author Nour, Matthew M.
Liu, Yunzhe
Arumuham, Atheeshaan
Kurth-Nelson, Zeb
Dolan, Raymond J.
author_facet Nour, Matthew M.
Liu, Yunzhe
Arumuham, Atheeshaan
Kurth-Nelson, Zeb
Dolan, Raymond J.
author_sort Nour, Matthew M.
collection PubMed
description An ability to build structured mental maps of the world underpins our capacity to imagine relationships between objects that extend beyond experience. In rodents, such representations are supported by sequential place cell reactivations during rest, known as replay. Schizophrenia is proposed to reflect a compromise in structured mental representations, with animal models reporting abnormalities in hippocampal replay and associated ripple activity during rest. Here, utilizing magnetoencephalography (MEG), we tasked patients with schizophrenia and control participants to infer unobserved relationships between objects by reorganizing visual experiences containing these objects. During a post-task rest session, controls exhibited fast spontaneous neural reactivation of presented objects that replayed inferred relationships. Replay was coincident with increased ripple power in hippocampus. Patients showed both reduced replay and augmented ripple power relative to controls, convergent with findings in animal models. These abnormalities are linked to impairments in behavioral acquisition and subsequent neural representation of task structure.
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spelling pubmed-83574252021-08-12 Impaired neural replay of inferred relationships in schizophrenia Nour, Matthew M. Liu, Yunzhe Arumuham, Atheeshaan Kurth-Nelson, Zeb Dolan, Raymond J. Cell Article An ability to build structured mental maps of the world underpins our capacity to imagine relationships between objects that extend beyond experience. In rodents, such representations are supported by sequential place cell reactivations during rest, known as replay. Schizophrenia is proposed to reflect a compromise in structured mental representations, with animal models reporting abnormalities in hippocampal replay and associated ripple activity during rest. Here, utilizing magnetoencephalography (MEG), we tasked patients with schizophrenia and control participants to infer unobserved relationships between objects by reorganizing visual experiences containing these objects. During a post-task rest session, controls exhibited fast spontaneous neural reactivation of presented objects that replayed inferred relationships. Replay was coincident with increased ripple power in hippocampus. Patients showed both reduced replay and augmented ripple power relative to controls, convergent with findings in animal models. These abnormalities are linked to impairments in behavioral acquisition and subsequent neural representation of task structure. Cell Press 2021-08-05 /pmc/articles/PMC8357425/ /pubmed/34197734 http://dx.doi.org/10.1016/j.cell.2021.06.012 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nour, Matthew M.
Liu, Yunzhe
Arumuham, Atheeshaan
Kurth-Nelson, Zeb
Dolan, Raymond J.
Impaired neural replay of inferred relationships in schizophrenia
title Impaired neural replay of inferred relationships in schizophrenia
title_full Impaired neural replay of inferred relationships in schizophrenia
title_fullStr Impaired neural replay of inferred relationships in schizophrenia
title_full_unstemmed Impaired neural replay of inferred relationships in schizophrenia
title_short Impaired neural replay of inferred relationships in schizophrenia
title_sort impaired neural replay of inferred relationships in schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357425/
https://www.ncbi.nlm.nih.gov/pubmed/34197734
http://dx.doi.org/10.1016/j.cell.2021.06.012
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