Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet

MATERIALS AND METHODS: Male apolipoprotein E-knockout mice fed a high-fat diet were divided into control (CTL), valsartan (30 mg/kg) (VAL), sacubitril (30 mg/kg) (SAC), and valsartan plus sacubitril (30 mg/kg each) (VAL/SAC) groups after 4 weeks of prefeeding and were subsequently treated for 12 wee...

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Detalles Bibliográficos
Autores principales: Suematsu, Yasunori, Tashiro, Kohei, Morita, Hidetaka, Ideishi, Akihito, Kuwano, Takashi, Miura, Shin-ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357528/
https://www.ncbi.nlm.nih.gov/pubmed/34394711
http://dx.doi.org/10.1155/2021/9916789

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