Cargando…
Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients
PURPOSE: To evaluate the effects of baseline trabecular meshwork (TM) and Schlemm’s canal (SC) microstructures on intraocular pressure (IOP) reduction amount in treatment-naïve patients with primary open-angle glaucoma (POAG). METHODS: A total 69 eyes of POAG patients who had not been treated with I...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Ophthalmological Society
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357607/ https://www.ncbi.nlm.nih.gov/pubmed/34162183 http://dx.doi.org/10.3341/kjo.2021.0007 |
_version_ | 1783737165582172160 |
---|---|
author | Chung, Hyun Woo Park, Ji-Hye Yoo, Chungkwon Kim, Yong Yeon |
author_facet | Chung, Hyun Woo Park, Ji-Hye Yoo, Chungkwon Kim, Yong Yeon |
author_sort | Chung, Hyun Woo |
collection | PubMed |
description | PURPOSE: To evaluate the effects of baseline trabecular meshwork (TM) and Schlemm’s canal (SC) microstructures on intraocular pressure (IOP) reduction amount in treatment-naïve patients with primary open-angle glaucoma (POAG). METHODS: A total 69 eyes of POAG patients who had not been treated with IOP-lowering agent were enrolled in this retrospective study. The patients had been prescribed topical IOP-lowering agent and used it for 1 year. The morphologic features of the TM and SC were collected using anterior segment module of spectral-domain optical coherence tomography with enhanced depth imaging at baseline. Images of the nasal and temporal corneoscleral limbus were obtained with serial horizontal enhanced depth imaging B-scans and TM width and SC area were measured in each scan. We investigated the effects of baseline TM and SC microstructures on IOP reduction amount. RESULTS: The baseline IOP of 69 glaucomatous eyes was 17.9 ± 3.8 mmHg, and the mean amount of IOP reduction was 3.5 ± 2.1 mmHg after 1 year. Mean TM widths of nasal and temporal sector were 470.33 ± 80.05 and 479.74 ± 79.59 μm, respectively. SC area was measured as 4,818.50 ± 1,464.28, 4,604.23 ± 1,567.73 μm(2) at nasal sector and temporal sector, respectively. The correlation analysis revealed a positive correlation between SC area and average amount of IOP reduction, indicating that the larger baseline SC area, the greater the IOP drop with topical IOP-lowering agents. However, no correlation was found between TM width and IOP lowering amount in patients with POAG. CONCLUSIONS: The baseline SC area showed positive correlation with the IOP reduction amount in patients with POAG. This finding suggests that the SC area can be a clinical parameter to predict the IOP reduction amount before using IOP-lowering agents in POAG patient. |
format | Online Article Text |
id | pubmed-8357607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Ophthalmological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-83576072021-08-16 Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients Chung, Hyun Woo Park, Ji-Hye Yoo, Chungkwon Kim, Yong Yeon Korean J Ophthalmol Original Article PURPOSE: To evaluate the effects of baseline trabecular meshwork (TM) and Schlemm’s canal (SC) microstructures on intraocular pressure (IOP) reduction amount in treatment-naïve patients with primary open-angle glaucoma (POAG). METHODS: A total 69 eyes of POAG patients who had not been treated with IOP-lowering agent were enrolled in this retrospective study. The patients had been prescribed topical IOP-lowering agent and used it for 1 year. The morphologic features of the TM and SC were collected using anterior segment module of spectral-domain optical coherence tomography with enhanced depth imaging at baseline. Images of the nasal and temporal corneoscleral limbus were obtained with serial horizontal enhanced depth imaging B-scans and TM width and SC area were measured in each scan. We investigated the effects of baseline TM and SC microstructures on IOP reduction amount. RESULTS: The baseline IOP of 69 glaucomatous eyes was 17.9 ± 3.8 mmHg, and the mean amount of IOP reduction was 3.5 ± 2.1 mmHg after 1 year. Mean TM widths of nasal and temporal sector were 470.33 ± 80.05 and 479.74 ± 79.59 μm, respectively. SC area was measured as 4,818.50 ± 1,464.28, 4,604.23 ± 1,567.73 μm(2) at nasal sector and temporal sector, respectively. The correlation analysis revealed a positive correlation between SC area and average amount of IOP reduction, indicating that the larger baseline SC area, the greater the IOP drop with topical IOP-lowering agents. However, no correlation was found between TM width and IOP lowering amount in patients with POAG. CONCLUSIONS: The baseline SC area showed positive correlation with the IOP reduction amount in patients with POAG. This finding suggests that the SC area can be a clinical parameter to predict the IOP reduction amount before using IOP-lowering agents in POAG patient. Korean Ophthalmological Society 2021-08 2021-06-21 /pmc/articles/PMC8357607/ /pubmed/34162183 http://dx.doi.org/10.3341/kjo.2021.0007 Text en © 2021 The Korean Ophthalmological Society https://creativecommons.org/licenses/by-nc/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chung, Hyun Woo Park, Ji-Hye Yoo, Chungkwon Kim, Yong Yeon Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients |
title | Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients |
title_full | Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients |
title_fullStr | Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients |
title_full_unstemmed | Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients |
title_short | Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients |
title_sort | effects of trabecular meshwork width and schlemm’s canal area on intraocular pressure reduction in glaucoma patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357607/ https://www.ncbi.nlm.nih.gov/pubmed/34162183 http://dx.doi.org/10.3341/kjo.2021.0007 |
work_keys_str_mv | AT chunghyunwoo effectsoftrabecularmeshworkwidthandschlemmscanalareaonintraocularpressurereductioninglaucomapatients AT parkjihye effectsoftrabecularmeshworkwidthandschlemmscanalareaonintraocularpressurereductioninglaucomapatients AT yoochungkwon effectsoftrabecularmeshworkwidthandschlemmscanalareaonintraocularpressurereductioninglaucomapatients AT kimyongyeon effectsoftrabecularmeshworkwidthandschlemmscanalareaonintraocularpressurereductioninglaucomapatients |