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Structural insights into how Prp5 proofreads the pre-mRNA branch site

During the splicing of introns from precursor messenger RNAs (pre-mRNAs), the U2 small nuclear ribonucleoprotein (snRNP) must undergo stable integration into the spliceosomal A complex—a poorly understood, multistep process that is facilitated by the DEAD-box helicase Prp5 (refs. (1–4)). During this...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhenwei, Rigo, Norbert, Dybkov, Olexandr, Fourmann, Jean-Baptiste, Will, Cindy L., Kumar, Vinay, Urlaub, Henning, Stark, Holger, Lührmann, Reinhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357632/ https://www.ncbi.nlm.nih.gov/pubmed/34349264 http://dx.doi.org/10.1038/s41586-021-03789-5

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