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Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle

Fatty acids (FA) play a crucial role in glycaemia regulation in healthy and metabolic disorders conditions through various mechanisms. FA oxidation is one of the processes involved in lipid metabolism and can be modulated by exercise. Nowadays, physical activity is known to be an effective strategy...

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Autores principales: Langlois, A., Forterre, A., Pinget, M., Bouzakri, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357749/
https://www.ncbi.nlm.nih.gov/pubmed/33844166
http://dx.doi.org/10.1007/s40618-021-01551-2
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author Langlois, A.
Forterre, A.
Pinget, M.
Bouzakri, K.
author_facet Langlois, A.
Forterre, A.
Pinget, M.
Bouzakri, K.
author_sort Langlois, A.
collection PubMed
description Fatty acids (FA) play a crucial role in glycaemia regulation in healthy and metabolic disorders conditions through various mechanisms. FA oxidation is one of the processes involved in lipid metabolism and can be modulated by exercise. Nowadays, physical activity is known to be an effective strategy for the prevention and treatment of Type 2 Diabetes. Moreover, its intensity, its duration, the sex-gender, the prandial state, exerkines… are as many parameters that can influence glycaemic control. However, the widely debated question is to determine the best type of exercise for patients with metabolic disorders. In this review, we will discuss the impact of exercise intensity, especially moderate activity, on glycaemic control by focussing on FA oxidation in pancreatic β-cells and skeletal muscle. Finally, thanks to all the recent data, we will determine whether moderate physical activity is a good therapeutic strategy and if FA oxidation represents a target of interest to treat diabetic, obese and insulin-resistant patients.
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spelling pubmed-83577492021-08-30 Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle Langlois, A. Forterre, A. Pinget, M. Bouzakri, K. J Endocrinol Invest Review Fatty acids (FA) play a crucial role in glycaemia regulation in healthy and metabolic disorders conditions through various mechanisms. FA oxidation is one of the processes involved in lipid metabolism and can be modulated by exercise. Nowadays, physical activity is known to be an effective strategy for the prevention and treatment of Type 2 Diabetes. Moreover, its intensity, its duration, the sex-gender, the prandial state, exerkines… are as many parameters that can influence glycaemic control. However, the widely debated question is to determine the best type of exercise for patients with metabolic disorders. In this review, we will discuss the impact of exercise intensity, especially moderate activity, on glycaemic control by focussing on FA oxidation in pancreatic β-cells and skeletal muscle. Finally, thanks to all the recent data, we will determine whether moderate physical activity is a good therapeutic strategy and if FA oxidation represents a target of interest to treat diabetic, obese and insulin-resistant patients. Springer International Publishing 2021-04-12 2021 /pmc/articles/PMC8357749/ /pubmed/33844166 http://dx.doi.org/10.1007/s40618-021-01551-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Langlois, A.
Forterre, A.
Pinget, M.
Bouzakri, K.
Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
title Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
title_full Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
title_fullStr Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
title_full_unstemmed Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
title_short Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
title_sort impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357749/
https://www.ncbi.nlm.nih.gov/pubmed/33844166
http://dx.doi.org/10.1007/s40618-021-01551-2
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