Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells

Stem and progenitor cells undergo a global elevation of nascent transcription, or hypertranscription, during key developmental transitions involving rapid cell proliferation. The chromatin remodeler Chd1 mediates hypertranscription in pluripotent cells but its mechanism of action remains poorly unde...

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Detalles Bibliográficos
Autores principales: Bulut-Karslioglu, Aydan, Jin, Hu, Kim, Yun-Kyo, Cho, Brandon, Guzman-Ayala, Marcela, Williamson, Andrew J. K., Hejna, Miroslav, Stötzel, Maximilian, Whetton, Anthony D., Song, Jun S., Ramalho-Santos, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357957/
https://www.ncbi.nlm.nih.gov/pubmed/34381042
http://dx.doi.org/10.1038/s41467-021-25088-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357957/
https://www.ncbi.nlm.nih.gov/pubmed/34381042
http://dx.doi.org/10.1038/s41467-021-25088-3

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