Cargando…

Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells

Stem and progenitor cells undergo a global elevation of nascent transcription, or hypertranscription, during key developmental transitions involving rapid cell proliferation. The chromatin remodeler Chd1 mediates hypertranscription in pluripotent cells but its mechanism of action remains poorly unde...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bulut-Karslioglu, Aydan, Jin, Hu, Kim, Yun-Kyo, Cho, Brandon, Guzman-Ayala, Marcela, Williamson, Andrew J. K., Hejna, Miroslav, Stötzel, Maximilian, Whetton, Anthony D., Song, Jun S., Ramalho-Santos, Miguel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357957/ https://www.ncbi.nlm.nih.gov/pubmed/34381042 http://dx.doi.org/10.1038/s41467-021-25088-3

Ejemplares similares

Inhibition of mTor induces a paused pluripotent state
por: Bulut-Karslioglu, Aydan, et al.
Publicado: (2016)

Widespread hypertranscription in aggressive human cancers
por: Zatzman, Matthew, et al.
Publicado: (2022)

Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids
por: López-Anguita, Natalia, et al.
Publicado: (2022)

RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry
por: Cucinotta, Christine E, et al.
Publicado: (2021)

The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription
por: Neil, Emily, et al.
Publicado: (2023)

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription
por: Lau, Mei Sheng, et al.
Publicado: (2023)

Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells
por: van der Weijden, Vera A., et al.
Publicado: (2021)

Embryonic stem cell differentiation requires full length Chd1
por: Piatti, Paolo, et al.
Publicado: (2015)

Morphological study of embryonic Chd8(+/−) mouse brains using light-sheet microscopy
por: Gómez, Harold F., et al.
Publicado: (2021)

Oral health status of CHD and non-CHD adults of Lahore, Pakistan
por: Bokhari, Syed Akhtar Hussain, et al.
Publicado: (2011)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells
por: Semba, Yuichiro, et al.
Publicado: (2017)

Progress in CHD Prevention
por: Lewis, Barry
Publicado: (1983)

CHD1 and CHD2 are positive regulators of HIV-1 gene expression
por: Rodgers, Melissa J, et al.
Publicado: (2014)

The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities
por: Manning, Benjamin J., et al.
Publicado: (2017)

Cerebellar Vermis and Midbrain Hypoplasia Upon Conditional Deletion of Chd7 from the Embryonic Mid-Hindbrain Region
por: Donovan, Alex P. A., et al.
Publicado: (2017)

CHD1 Regulates Deposition of Histone Variant H3.3 During Bovine Early Embryonic Development
por: Zhang, Kun, et al.
Publicado: (2016)

The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development
por: Xie, Jun, et al.
Publicado: (2020)

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8
por: Marie, Corentine, et al.
Publicado: (2018)

Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood
por: Piazzi, Manuela, et al.
Publicado: (2015)

Photosensitivity and CHD2 Variants
por: Sosa, Rebecca García, et al.
Publicado: (2015)

Differential Expression and Sex Chromosome Association of CHD3/4 and CHD5 during Spermatogenesis
por: Bergs, Judith W., et al.
Publicado: (2014)

Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD
por: Liu, Weijing, et al.
Publicado: (2019)

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality
por: Hoffmeister, Helen, et al.
Publicado: (2017)

Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency
por: Wade, A. Ayanna, et al.
Publicado: (2019)

The NuRD Chromatin-Remodeling Enzyme CHD4 Promotes Embryonic Vascular Integrity by Transcriptionally Regulating Extracellular Matrix Proteolysis
por: Ingram, Kyle G., et al.
Publicado: (2013)

CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expression
por: Yao, Hui, et al.
Publicado: (2020)

Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia
por: Zhang, Rong, et al.
Publicado: (2020)

CHD4 Conceals Aberrant CTCF-Binding Sites at TAD Interiors by Regulating Chromatin Accessibility in Mouse Embryonic Stem Cells
por: Han, Sungwook, et al.
Publicado: (2021)

CHD2-Related CNS Pathologies
por: Wilson, Marc-Michel, et al.
Publicado: (2021)

CHD5 inhibits metastasis of neuroblastoma
por: Laut, Astrid K., et al.
Publicado: (2021)

Green tea consumption is associated with reduced incident CHD and improved CHD-related biomarkers in the Dongfeng-Tongji cohort
por: Tian, Chong, et al.
Publicado: (2016)

ATP-Dependent Chromatin Remodeler CHD9 Controls the Proliferation of Embryonic Stem Cells in a Cell Culture Condition-Dependent Manner
por: Yoo, Hyunjin, et al.
Publicado: (2020)

Corrigendum to: CHD4 Conceals Aberrant CTCF-Binding Sites at TAD Interiors by Regulating Chromatin Accessibility in Mouse Embryonic Stem Cells
por: Han, Sungwook, et al.
Publicado: (2022)

Graded Smad2/3 Activation Is Converted Directly into Levels of Target Gene Expression in Embryonic Stem Cells
por: Guzman-Ayala, Marcela, et al.
Publicado: (2009)

In Vitro Susceptibilities of Candida albicans Isolates to Antifungal Agents in Tokat, Turkey
por: Yenisehirli, Gulgun, et al.
Publicado: (2015)

Identification and Characterization of FAM124B as a Novel Component of a CHD7 and CHD8 Containing Complex
por: Batsukh, Tserendulam, et al.
Publicado: (2012)

Genotranscriptomic meta‐analysis of the CHD family chromatin remodelers in human cancers – initial evidence of an oncogenic role for CHD7
por: Chu, Xiaofang, et al.
Publicado: (2017)

Corrigendum: Green tea consumption is associated with reduced incident CHD and improved CHD-related biomarkers in the Dongfeng-Tongji cohort
por: Tian, Chong, et al.
Publicado: (2017)

Patient Perspectives on Factors Influencing Medication Adherence Among People with Coronary Heart Disease (CHD) and CHD Risk Factors
por: Mondesir, Favel L, et al.
Publicado: (2019)

The Effect of TNF-α on CHD and the Relationship between TNF-α Antagonist and CHD in Rheumatoid Arthritis: A Systematic Review
por: Qian, Yezhou, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0hui6t4rgct460crn96fj27q6e