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Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling

The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in...

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Autores principales: Mishra, Swapnil, Scott, James A., Laydon, Daniel J., Flaxman, Seth, Gandy, Axel, Mellan, Thomas A., Unwin, H. Juliette T., Vollmer, Michaela, Coupland, Helen, Ratmann, Oliver, Monod, Melodie, Zhu, Harrison H., Cori, Anne, Gaythorpe, Katy A. M., Whittles, Lilith K., Whittaker, Charles, Donnelly, Christl A., Ferguson, Neil M., Bhatt, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358009/
https://www.ncbi.nlm.nih.gov/pubmed/34381102
http://dx.doi.org/10.1038/s41598-021-95699-9
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author Mishra, Swapnil
Scott, James A.
Laydon, Daniel J.
Flaxman, Seth
Gandy, Axel
Mellan, Thomas A.
Unwin, H. Juliette T.
Vollmer, Michaela
Coupland, Helen
Ratmann, Oliver
Monod, Melodie
Zhu, Harrison H.
Cori, Anne
Gaythorpe, Katy A. M.
Whittles, Lilith K.
Whittaker, Charles
Donnelly, Christl A.
Ferguson, Neil M.
Bhatt, Samir
author_facet Mishra, Swapnil
Scott, James A.
Laydon, Daniel J.
Flaxman, Seth
Gandy, Axel
Mellan, Thomas A.
Unwin, H. Juliette T.
Vollmer, Michaela
Coupland, Helen
Ratmann, Oliver
Monod, Melodie
Zhu, Harrison H.
Cori, Anne
Gaythorpe, Katy A. M.
Whittles, Lilith K.
Whittaker, Charles
Donnelly, Christl A.
Ferguson, Neil M.
Bhatt, Samir
author_sort Mishra, Swapnil
collection PubMed
description The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others’ policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country’s first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.
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spelling pubmed-83580092021-08-13 Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling Mishra, Swapnil Scott, James A. Laydon, Daniel J. Flaxman, Seth Gandy, Axel Mellan, Thomas A. Unwin, H. Juliette T. Vollmer, Michaela Coupland, Helen Ratmann, Oliver Monod, Melodie Zhu, Harrison H. Cori, Anne Gaythorpe, Katy A. M. Whittles, Lilith K. Whittaker, Charles Donnelly, Christl A. Ferguson, Neil M. Bhatt, Samir Sci Rep Article The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others’ policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country’s first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic. Nature Publishing Group UK 2021-08-11 /pmc/articles/PMC8358009/ /pubmed/34381102 http://dx.doi.org/10.1038/s41598-021-95699-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mishra, Swapnil
Scott, James A.
Laydon, Daniel J.
Flaxman, Seth
Gandy, Axel
Mellan, Thomas A.
Unwin, H. Juliette T.
Vollmer, Michaela
Coupland, Helen
Ratmann, Oliver
Monod, Melodie
Zhu, Harrison H.
Cori, Anne
Gaythorpe, Katy A. M.
Whittles, Lilith K.
Whittaker, Charles
Donnelly, Christl A.
Ferguson, Neil M.
Bhatt, Samir
Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
title Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
title_full Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
title_fullStr Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
title_full_unstemmed Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
title_short Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling
title_sort comparing the responses of the uk, sweden and denmark to covid-19 using counterfactual modelling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358009/
https://www.ncbi.nlm.nih.gov/pubmed/34381102
http://dx.doi.org/10.1038/s41598-021-95699-9
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