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Substitution of I222L-E119V in neuraminidase from highly pathogenic avian influenza H7N9 virus exhibited synergistic resistance effect to oseltamivir in mice

That the high frequency and good replication capacity of strains with reduced susceptibility to neuraminidase inhibitors (NAIs) in highly pathogenic avian influenza H7N9 (HPAI H7N9) virus made it a significance to further study its drug resistance. HPAI H7N9 viruses bearing NA I222L or E119V substit...

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Detalles Bibliográficos
Autores principales:	Tang, Jing, Gao, Rongbao, Liu, Liqi, Zhang, Shuxia, Liu, Jia, Li, Xiyan, Fang, Qiongqiong, Feng, Zhaomin, Xu, Cuiling, Huang, Weijuan, Wang, Dayan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358046/ https://www.ncbi.nlm.nih.gov/pubmed/34381119 http://dx.doi.org/10.1038/s41598-021-95771-4

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