A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed in endothelial cells (ECs), where it finely controls developmental and tumor angiogenesis. In the absence of Netrin-1, UNC5B induces apoptosis that is blocked upon Netrin-1 binding. Here, we identify an UNC5B splicing i...

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Detalles Bibliográficos
Autores principales: Pradella, Davide, Deflorian, Gianluca, Pezzotta, Alex, Di Matteo, Anna, Belloni, Elisa, Campolungo, Daniele, Paradisi, Andrea, Bugatti, Mattia, Vermi, William, Campioni, Matteo, Chiapparino, Antonella, Scietti, Luigi, Forneris, Federico, Giampietro, Costanza, Volf, Nina, Rehman, Michael, Zacchigna, Serena, Paronetto, Maria Paola, Pistocchi, Anna, Eichmann, Anne, Mehlen, Patrick, Ghigna, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358048/
https://www.ncbi.nlm.nih.gov/pubmed/34381052
http://dx.doi.org/10.1038/s41467-021-24998-6

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