Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia

Acute leukemia relapsing after chemotherapy plus allogeneic hematopoietic stem cell transplantation can be treated with donor-derived T cells, but this is hampered by the need for donor/recipient MHC-matching and often results in graft-versus-host disease, prompting the search for new donor-unrestri...

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Detalles Bibliográficos
Autores principales: Consonni, Michela, Garavaglia, Claudio, Grilli, Andrea, de Lalla, Claudia, Mancino, Alessandra, Mori, Lucia, De Libero, Gennaro, Montagna, Daniela, Casucci, Monica, Serafini, Marta, Bonini, Chiara, Häussinger, Daniel, Ciceri, Fabio, Bernardi, Massimo, Mastaglio, Sara, Bicciato, Silvio, Dellabona, Paolo, Casorati, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358059/
https://www.ncbi.nlm.nih.gov/pubmed/34381053
http://dx.doi.org/10.1038/s41467-021-25223-0

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