Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity

Phytochemical studies on the rhizomes of Actaea asiatica led to the isolation of seven new cycloartane triterpenes, actaticas A−G (1−7). Their structures were determined by NMR, HRESIMS, and chemical analysis. All the isolates were evaluated for their antiproliferative activity against HT-29 and McF...

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Autores principales: Hu, Meigeng, Zhao, Dan, Xu, Xudong, Ma, Guoxu, Wu, Haifeng, Chen, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358065/
https://www.ncbi.nlm.nih.gov/pubmed/34395378
http://dx.doi.org/10.3389/fchem.2021.695456
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author Hu, Meigeng
Zhao, Dan
Xu, Xudong
Ma, Guoxu
Wu, Haifeng
Chen, Xi
author_facet Hu, Meigeng
Zhao, Dan
Xu, Xudong
Ma, Guoxu
Wu, Haifeng
Chen, Xi
author_sort Hu, Meigeng
collection PubMed
description Phytochemical studies on the rhizomes of Actaea asiatica led to the isolation of seven new cycloartane triterpenes, actaticas A−G (1−7). Their structures were determined by NMR, HRESIMS, and chemical analysis. All the isolates were evaluated for their antiproliferative activity against HT-29 and McF-7 cell lines. The results showed that all the compounds displayed cytotoxicity. All compounds showed significant inhibitory effects with IC(50) values of 9.2–26.4 μM.
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spelling pubmed-83580652021-08-13 Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity Hu, Meigeng Zhao, Dan Xu, Xudong Ma, Guoxu Wu, Haifeng Chen, Xi Front Chem Chemistry Phytochemical studies on the rhizomes of Actaea asiatica led to the isolation of seven new cycloartane triterpenes, actaticas A−G (1−7). Their structures were determined by NMR, HRESIMS, and chemical analysis. All the isolates were evaluated for their antiproliferative activity against HT-29 and McF-7 cell lines. The results showed that all the compounds displayed cytotoxicity. All compounds showed significant inhibitory effects with IC(50) values of 9.2–26.4 μM. Frontiers Media S.A. 2021-07-29 /pmc/articles/PMC8358065/ /pubmed/34395378 http://dx.doi.org/10.3389/fchem.2021.695456 Text en Copyright © 2021 Hu, Zhao, Xu, Ma, Wu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Hu, Meigeng
Zhao, Dan
Xu, Xudong
Ma, Guoxu
Wu, Haifeng
Chen, Xi
Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity
title Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity
title_full Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity
title_fullStr Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity
title_full_unstemmed Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity
title_short Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity
title_sort actaticas a−g, cycloartane triterpenes from actaea asiatica with their antiproliferative activity
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358065/
https://www.ncbi.nlm.nih.gov/pubmed/34395378
http://dx.doi.org/10.3389/fchem.2021.695456
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